Irak4 MGI Mouse Gene Detail - MGI:2182474 - interleukin-1 receptor-associated kinase 4

Symbol

Irak4
Name

interleukin-1 receptor-associated kinase 4
Synonyms

8430405M07Rik, 9330209D03Rik, IRAK-4, NY-REN-64

Feature Type

protein coding gene
IDs

MGI:2182474
NCBI Gene: 266632
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr15:94441495-94466198 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 48.55 cM, cytoband F1
Mapping Data

3 experiments

SNPs within 2kb

914 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2182474	protein coding gene	Chr15:94441495-94479696 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022260	protein coding gene	Chr15:96013871-96053592 (+)
A/J	MGP_AJ_G0022219	protein coding gene	Chr15:92277729-92316479 (+)
AKR/J	MGP_AKRJ_G0022194	protein coding gene	Chr15:95067962-95105945 (+)
BALB/cJ	MGP_BALBcJ_G0022225	protein coding gene	Chr15:92440515-92481021 (+)
C3H/HeJ	MGP_C3HHeJ_G0021995	protein coding gene	Chr15:95080058-95122835 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022670	protein coding gene	Chr15:99524047-99571407 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020196	protein coding gene	Chr15:88303295-88328755 (+)
CAST/EiJ	MGP_CASTEiJ_G0021517	protein coding gene	Chr15:95895703-95924395 (+)
CBA/J	MGP_CBAJ_G0021962	protein coding gene	Chr15:102879750-102924564 (+)
DBA/2J	MGP_DBA2J_G0022089	protein coding gene	Chr15:91724162-91762868 (+)
FVB/NJ	MGP_FVBNJ_G0022068	protein coding gene	Chr15:90728052-90766020 (+)
LP/J	MGP_LPJ_G0022160	protein coding gene	Chr15:96131738-96171587 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022088	protein coding gene	Chr15:107175730-107203980 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022685	protein coding gene	Chr15:95141641-95188918 (+)
PWK/PhJ	MGP_PWKPhJ_G0021258	protein coding gene	Chr15:91781442-91807961 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021092	protein coding gene	Chr15:94887600-94931030 (+)
WSB/EiJ	MGP_WSBEiJ_G0021566	protein coding gene	Chr15:95645872-95692106 (+)

Human Ortholog

IRAK4, interleukin 1 receptor associated kinase 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IRAK4, interleukin 1 receptor associated kinase 4
Synonyms

IMD67, IPD1, IRAK-4, NY-REN-64, REN64
Links

HGNC:17967

NCBI Gene ID: 51135

neXtProt AC: NX_Q9NWZ3

UniProt: Q9NWZ3
Chr Location

12q12; chr12:43758944-43798307 (+) GRCh38

MGI Vertebrate Homology

Irak4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IRAK4
Protein SuperFamily

IRAK4
Gene Tree

Irak4

Diseases

1 with human IRAK4 associations

				Human Disease	Mouse Models
				primary immunodeficiency disease IDs primary immunodeficiency disease DOID:612 ICD10CM:D84.9 ICD9CM:279.3 KEGG:05340 MESH:D007153 NCI:C39725 OMIM:242850 OMIM:PS300755 UMLS_CUI:C0021051

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

25 phenotypes from 6 alleles in 6 genetic backgrounds
8 phenotypes from multigenic genotypes
63 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

2
Targeted

7
Genomic Mutations

3 involving Irak4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice exhibit defects of the innate immune system and show increased susceptibility to bacterial infection.

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All GO Annotations

61
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

778
Tissues

49
cDNA Data

17
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase irak4

ZFIN irak4

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All Sequences

41
RefSeq

4
UniProt

3
CCDS

CCDS27772.1

Ensembl

ENSMUSG00000059883 (Evidence)
NCBI Gene

266632

			Length	Strain/Species	Flank
genomic	266632	NCBI Gene Model \| MGI Sequence Detail	24704	C57BL/6J	± kb
transcript	NM_029926	RefSeq \| MGI Sequence Detail	2825	C57BL/6
polypeptide	Q8R4K2	UniProt \| EBI \| MGI Sequence Detail	459	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000001780 interleukin-1 receptor-associated kinase 4

(term hierarchy)
PDB

1WH4, 2A9I
EC

2.7.11.1
InterPro Domains

IPR000488 Death domain

IPR011029 Death-like domain superfamily

IPR050885 Innate Immune Response and Plant Defense Kinases

IPR017428 Interleukin-1 receptor-associated kinase 4

IPR037970 IRAK4, Death domain

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

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All nucleic 18

cDNA 17

Primer pair 1

Microarray probesets 4

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MGI:1918735, MGI:1924812

Summaries

All 122

Developmental Gene Expression 3

Diseases 1

Gene Ontology 17

Phenotypes 63
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:351632 Menoret A, et al., IRAK4 is an immunological checkpoint in neuropsychiatric systemic lupus erythematosus. Sci Rep. 2024 Jul 16;14(1):16393

TSS for Irak4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132780	Chr15:94441486-94441539 (+)	18 bp
Tssr132781	Chr15:94441547-94441562 (+)	60 bp
Tssr132782	Chr15:94442141-94442149 (+)	650 bp
Tssr132783	Chr15:94459464-94459478 (+)	17,976 bp
Tssr132784	Chr15:94464955-94464961 (+)	23,463 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24