Grhl1 MGI Mouse Gene Detail - MGI:2182540 - grainyhead like transcription factor 1

Symbol

Grhl1
Name

grainyhead like transcription factor 1
Synonyms

LBP-32, p61 MGR, p70 MGR, Tcfcp2l2

Feature Type

protein coding gene
IDs

MGI:2182540
NCBI Gene: 195733
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr12:24622282-24667390 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 8.49 cM
Mapping Data

2 experiments

SNPs within 2kb

1308 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2182540	protein coding gene	Chr12:24622234-24667390 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019629	protein coding gene	Chr12:22250362-22298258 (+)
A/J	MGP_AJ_G0019596	protein coding gene	Chr12:21645115-21690316 (+)
AKR/J	MGP_AKRJ_G0019567	protein coding gene	Chr12:22375589-22420617 (+)
BALB/cJ	MGP_BALBcJ_G0019573	protein coding gene	Chr12:21914734-21960154 (+)
C3H/HeJ	MGP_C3HHeJ_G0019377	protein coding gene	Chr12:22255241-22300383 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020021	protein coding gene	Chr12:22935708-22980602 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017645	protein coding gene	Chr12:21127934-21172280 (+)
CAST/EiJ	MGP_CASTEiJ_G0018932	protein coding gene	Chr12:17200980-17248155 (+)
CBA/J	MGP_CBAJ_G0019348	protein coding gene	Chr12:23662649-23713134 (+)
DBA/2J	MGP_DBA2J_G0019462	protein coding gene	Chr12:21497811-21542834 (+)
FVB/NJ	MGP_FVBNJ_G0019453	protein coding gene	Chr12:21388129-21434122 (+)
LP/J	MGP_LPJ_G0019532	protein coding gene	Chr12:22319566-22365891 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019488	protein coding gene	Chr12:23535129-23581824 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020060	protein coding gene	Chr12:21932290-21980058 (+)
PWK/PhJ	MGP_PWKPhJ_G0018699	protein coding gene	Chr12:16225109-16271211 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018487	protein coding gene	Chr12:16436056-16480966 (+)
WSB/EiJ	MGP_WSBEiJ_G0018983	protein coding gene	Chr12:22088220-22134327 (+)

Human Ortholog

GRHL1, grainyhead like transcription factor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GRHL1, grainyhead like transcription factor 1
Synonyms

LBP32, MGR, NH32, TFCP2L2
Links

HGNC:17923

NCBI Gene ID: 29841

neXtProt AC: NX_Q9NZI5

UniProt: Q9NZI5
Chr Location

2p25.1; chr2:9951693-10002277 (+) GRCh38

MGI Vertebrate Homology

Grhl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GRHL1
Gene Tree

Grhl1

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Phenotype Summary

11 phenotypes from 3 alleles in 3 genetic backgrounds
4 phenotypes from multigenic genotypes
5 images
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (ENU)

1
Endonuclease-mediated

2
Spontaneous

1
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display alopecia or sparse hair, abnormal hair follicle root sheaths, thickening of the cornified layer on the paws, and postnatal growth retardation.

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All GO Annotations

35
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1025
Tissues

201
cDNA Data

63
Literature Summary

18

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA GRHL1

Xenbase grhl1

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All Sequences

53
RefSeq

12
UniProt

2
CCDS

CCDS36420.1, CCDS49038.1

Ensembl

ENSMUSG00000020656 (Evidence)
NCBI Gene

195733

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020656	Ensembl Gene Model \| MGI Sequence Detail	45109	C57BL/6J	± kb
transcript	ENSMUST00000085553	Ensembl \| MGI Sequence Detail	3469	Not Applicable
polypeptide	ENSMUSP00000082689	Ensembl \| MGI Sequence Detail	618	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008229 grainyhead-like protein 1

(term hierarchy)
InterPro Domains

IPR007604 CP2 transcription factor

IPR040167 Transcription factor CP2-like
GlyGen

Q921D9 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 65

cDNA 63

Primer pair 2

Microarray probesets 4

Summaries

All 49

Developmental Gene Expression 18

Gene Ontology 8

Phenotypes 10
Earliest

J:76635 Wilanowski T, et al., A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead. Mech Dev. 2002 Jun;114(1-2):37-50
Latest

J:341642 Schwartz B, et al., ZNF750 Regulates Skin Barrier Function by Driving Cornified Envelope and Lipid Processing Pathways. J Invest Dermatol. 2023 Sep 3;

TSS for Grhl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112947	Chr12:24622248-24622265 (+)	-25 bp
Tssr112948	Chr12:24622275-24622307 (+)	9 bp
Tssr112949	Chr12:24622310-24622324 (+)	35 bp
Tssr112950	Chr12:24622399-24622428 (+)	132 bp
Tssr112951	Chr12:24622432-24622457 (+)	163 bp
Tssr112952	Chr12:24622577-24622588 (+)	301 bp
Tssr112953	Chr12:24622620-24622632 (+)	344 bp
Tssr112954	Chr12:24625825-24625828 (+)	3,545 bp
Tssr112955	Chr12:24631498-24631528 (+)	9,231 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24