Med17 MGI Mouse Gene Detail - MGI:2182585 - mediator complex subunit 17

Symbol

Med17
Name

mediator complex subunit 17
Synonyms

C330002H14Rik, Crsp6, Trap80

Feature Type

protein coding gene
IDs

MGI:2182585
NCBI Gene: 234959
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr9:15171647-15191227 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 4.74 cM
Mapping Data

1 experiment

SNPs within 2kb

649 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2182585	protein coding gene	Chr9:15171647-15194576 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034362	protein coding gene	Chr9:12238718-12259685 (-)
A/J	MGP_AJ_G0034340	protein coding gene	Chr9:12175842-12195342 (-)
AKR/J	MGP_AKRJ_G0034268	protein coding gene	Chr9:12193396-12212901 (-)
BALB/cJ	MGP_BALBcJ_G0034334	protein coding gene	Chr9:11946720-11966223 (-)
C3H/HeJ	MGP_C3HHeJ_G0034045	protein coding gene	Chr9:12509678-12529957 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034856	protein coding gene	Chr9:12640248-12659751 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031794	protein coding gene	Chr9:11444713-11463936 (-)
CAST/EiJ	MGP_CASTEiJ_G0033372	protein coding gene	Chr9:12348966-12369857 (-)
CBA/J	MGP_CBAJ_G0034018	protein coding gene	Chr9:13230414-13249930 (-)
DBA/2J	MGP_DBA2J_G0034175	protein coding gene	Chr9:12035603-12055116 (-)
FVB/NJ	MGP_FVBNJ_G0034120	protein coding gene	Chr9:11627311-11646801 (-)
LP/J	MGP_LPJ_G0034261	protein coding gene	Chr9:12342773-12362272 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034164	protein coding gene	Chr9:14244071-14263624 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034875	protein coding gene	Chr9:12228872-12248375 (-)
PWK/PhJ	MGP_PWKPhJ_G0033078	protein coding gene	Chr9:12113558-12133443 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032914	protein coding gene	Chr9:12331733-12353150 (-)
WSB/EiJ	MGP_WSBEiJ_G0033488	protein coding gene	Chr9:12067439-12086982 (-)

Human Ortholog

MED17, mediator complex subunit 17

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MED17, mediator complex subunit 17
Synonyms

CRSP6, CRSP77, DRIP80, SRB4, TRAP80
Links

HGNC:2375

NCBI Gene ID: 9440

neXtProt AC: NX_Q9NVC6

UniProt: Q9NVC6
Chr Location

11q21; chr11:93784227-93814963 (+) GRCh38

MGI Vertebrate Homology

Med17 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MED17
Gene Tree

Med17

Diseases

1 with human MED17 associations

				Human Disease	Mouse Models
				infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly IDs infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly DOID:0111262 OMIM:613668 ORDO:402364

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Gene trapped

2
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available

Homozygous knockout leads to reduced body weight, breathing difficulties and thymus hypoplasia. Mice die between birth and age eight weeks as a result of abdominal and pulmonary haemorrhage and heart failure.

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All GO Annotations

32
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

733
Tissues

17
cDNA Data

83
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MED17

Xenbase med17

ZFIN med17

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All Sequences

51
RefSeq

6
UniProt

3
CCDS

CCDS22834.1

Ensembl

ENSMUSG00000031935 (Evidence)
NCBI Gene

234959

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031935	Ensembl Gene Model \| MGI Sequence Detail	19581	C57BL/6J	± kb
transcript	ENSMUST00000034411	Ensembl \| MGI Sequence Detail	3964	Not Applicable
polypeptide	ENSMUSP00000034411	Ensembl \| MGI Sequence Detail	649	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010289 mediator of RNA polymerase II transcription subunit 17

(term hierarchy)
PDB

6W1S, 8T1I
InterPro Domains

IPR019313 Mediator complex, subunit Med17

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All nucleic 84

cDNA 83

Primer pair 1

Microarray probesets 4

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MGI:2443890

Summaries

All 46

Developmental Gene Expression 4

Gene Ontology 12

Phenotypes 8
Earliest

J:320035 Mittler G, et al., Novel critical role of a human Mediator complex for basal RNA polymerase II transcription. EMBO Rep. 2001 Sep;2(9):808-13
Latest

J:347774 Kolonay DW, et al., Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease. Front Cell Dev Biol. 2024;12:1331563

TSS for Med17:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr2786	Chr9:15191218-15191223 (-)	6 bp
Tssr88234	Chr9:15191184-15191215 (-)	27 bp
Tssr88233	Chr9:15191156-15191173 (-)	62 bp
Tssr88232	Chr9:15191143-15191152 (-)	79 bp
Tssr88231	Chr9:15190657-15190662 (-)	567 bp
Tssr88230	Chr9:15190085-15190089 (-)	1,140 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24