Acsf3 MGI Mouse Gene Detail - MGI:2182591 - acyl-CoA synthetase family member 3

Symbol

Acsf3
Name

acyl-CoA synthetase family member 3
Synonyms

MGC:37904

Feature Type

protein coding gene
IDs

MGI:2182591
NCBI Gene: 257633
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr8:123502225-123544619 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 71.97 cM
Mapping Data

1 experiment

SNPs within 2kb

1101 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2182591	protein coding gene	Chr8:123502209-123544626 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034237	protein coding gene	Chr8:126346128-126386150 (+)
A/J	MGP_AJ_G0034217	protein coding gene	Chr8:121107773-121154692 (+)
AKR/J	MGP_AKRJ_G0034144	protein coding gene	Chr8:124642262-124687307 (+)
BALB/cJ	MGP_BALBcJ_G0034211	protein coding gene	Chr8:121306480-121351023 (+)
C3H/HeJ	MGP_C3HHeJ_G0033921	protein coding gene	Chr8:125342988-125384354 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034730	protein coding gene	Chr8:130577626-130618037 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031672	protein coding gene	Chr8:113939641-113979768 (+)
CAST/EiJ	MGP_CASTEiJ_G0033249	protein coding gene	Chr8:125422066-125462134 (+)
CBA/J	MGP_CBAJ_G0033894	protein coding gene	Chr8:135359563-135399786 (+)
DBA/2J	MGP_DBA2J_G0034051	protein coding gene	Chr8:120296927-120337597 (+)
FVB/NJ	MGP_FVBNJ_G0033994	protein coding gene	Chr8:119447900-119488578 (+)
LP/J	MGP_LPJ_G0034140	protein coding gene	Chr8:126471194-126512891 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034041	protein coding gene	Chr8:137506401-137546957 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034749	protein coding gene	Chr8:124821723-124861973 (+)
PWK/PhJ	MGP_PWKPhJ_G0032950	protein coding gene	Chr8:120117865-120159422 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032790	protein coding gene	Chr8:123549554-123587964 (+)
WSB/EiJ	MGP_WSBEiJ_G0033365	protein coding gene	Chr8:125579040-125626262 (+)

Human Ortholog

ACSF3, acyl-CoA synthetase family member 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACSF3, acyl-CoA synthetase family member 3
Links

HGNC:27288

NCBI Gene ID: 197322

neXtProt AC: NX_Q4G176

UniProt: Q4G176
Chr Location

16q24.3; chr16:89088375-89164121 (+) GRCh38

MGI Vertebrate Homology

Acsf3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ACSF3
Gene Tree

Acsf3

Diseases

1 with human ACSF3 associations

				Human Disease	Mouse Models
				combined malonic and methylmalonic acidemia IDs combined malonic and methylmalonic acidemia DOID:0111263 MESH:C580002 OMIM:614265 ORDO:289504 UMLS_CUI:C3280314

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

18
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

41
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acsf3

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All Sequences

56
RefSeq

14
UniProt

2
CCDS

CCDS40505.1

Ensembl

ENSMUSG00000015016 (Evidence)
NCBI Gene

257633

			Length	Strain/Species	Flank
genomic	ENSMUSG00000015016	Ensembl Gene Model \| MGI Sequence Detail	42395	C57BL/6J	± kb
transcript	ENSMUST00000015160	Ensembl \| MGI Sequence Detail	2206	Not Applicable
polypeptide	ENSMUSP00000015160	Ensembl \| MGI Sequence Detail	583	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000003658 malonate--CoA ligase ACSF3, mitochondrial

(term hierarchy)
EC

6.2.1.76
InterPro Domains

IPR020845 AMP-binding, conserved site

IPR025110 AMP-binding enzyme, C-terminal domain

IPR045851 AMP-binding enzyme, C-terminal domain superfamily

IPR000873 AMP-dependent synthetase/ligase domain

IPR042099 ANL, N-terminal domain

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All nucleic 41

cDNA 41

Microarray probesets 5

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MGI:2144599

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 7
Earliest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Acsf3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr2719	Chr8:123502222-123502233 (+)	3 bp
Tssr79896	Chr8:123502236-123502253 (+)	20 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24