Adgrf2 MGI Mouse Gene Detail - MGI:2182728 - adhesion G protein-coupled receptor F2

Symbol

Adgrf2
Name

adhesion G protein-coupled receptor F2
Synonyms

Gpr111, PGR20

Feature Type

protein coding gene
IDs

MGI:2182728
NCBI Gene: 435529
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:43007021-43053070 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 19.66 cM
Mapping Data

1 experiment

SNPs within 2kb

1706 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2182728	protein coding gene	Chr17:43004919-43054646 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023769	protein coding gene	Chr17:43560734-43593375 (-)
A/J	MGP_AJ_G0023727	protein coding gene	Chr17:42582378-42619018 (-)
AKR/J	MGP_AKRJ_G0023698	protein coding gene	Chr17:42772022-42811915 (-)
BALB/cJ	MGP_BALBcJ_G0023731	protein coding gene	Chr17:42488367-42522064 (-)
C3H/HeJ	MGP_C3HHeJ_G0023495	protein coding gene	Chr17:43471754-43507491 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024173	protein coding gene	Chr17:45462000-45502942 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021624	protein coding gene	Chr17:39473729-39515260 (-)
CAST/EiJ	MGP_CASTEiJ_G0022976	protein coding gene	Chr17:43474585-43528904 (-)
CBA/J	MGP_CBAJ_G0023471	protein coding gene	Chr17:47116977-47156412 (-)
DBA/2J	MGP_DBA2J_G0023597	protein coding gene	Chr17:41396467-41430514 (-)
FVB/NJ	MGP_FVBNJ_G0023564	protein coding gene	Chr17:40946809-40992100 (-)
LP/J	MGP_LPJ_G0023678	protein coding gene	Chr17:44202886-44251198 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023593	protein coding gene	Chr17:46743137-46797219 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024219	protein coding gene	Chr17:43090864-43138999 (-)
PWK/PhJ	MGP_PWKPhJ_G0022721	protein coding gene	Chr17:40637591-40690040 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022536	protein coding gene	Chr17:40031833-40068476 (-)
WSB/EiJ	MGP_WSBEiJ_G0023041	protein coding gene	Chr17:43623612-43680007 (-)

Human Ortholog

ADGRF2P, adhesion G protein-coupled receptor F2, pseudogene

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADGRF2P, adhesion G protein-coupled receptor F2, pseudogene
Synonyms

ADGRF2, GPR111, hGPCR35, PGR20
Links

HGNC:18991

NCBI Gene ID: 222611

neXtProt AC: NX_Q8IZF7

UniProt: Q8IZF7
Chr Location

6p12.3; chr6:47656472-47697794 (+) GRCh38

MGI Vertebrate Homology

Adgrf2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ADGRF2P
Gene Tree

Adgrf2

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Phenotype Summary

3 phenotypes from 2 alleles in 3 genetic backgrounds
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

1
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available

Mice homozygous for a reporter allele exhibit normal viability and fertility. Mice homozygous for a different null allele exhibit dental enamel hypomineralization.

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All GO Annotations

6
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

27
cDNA Data

3
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

36
RefSeq

4
UniProt

4
CCDS

CCDS28792.2

Ensembl

ENSMUSG00000057899 (Evidence)
NCBI Gene

435529

			Length	Strain/Species	Flank
genomic	ENSMUSG00000057899	Ensembl Gene Model \| MGI Sequence Detail	46050	C57BL/6J	± kb
transcript	ENSMUST00000239223	Ensembl \| MGI Sequence Detail	2544	Not Applicable
polypeptide	ENSMUSP00000159259	Ensembl \| MGI Sequence Detail	673	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000031052 putative adhesion G protein-coupled receptor F2P

(term hierarchy)
InterPro Domains

IPR051587 Adhesion G-protein coupled receptor

IPR046338 GAIN domain superfamily

IPR008078 GPCR family 2, Ig-hepta-like receptor

IPR017981 GPCR, family 2-like, 7TM

IPR000832 GPCR, family 2, secretin-like

IPR000203 GPS motif
GlyGen

E9Q4J9 7 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)

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All nucleic 4

cDNA 3

Primer pair 1

Microarray probesets 1

Summaries

All 23

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 3
Earliest

J:90622 Bjarnadottir TK, et al., The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics. 2004 Jul;84(1):23-33
Latest

J:341655 Chiba Y, et al., Deficiency of G protein-coupled receptor Gpr111/Adgrf2 causes enamel hypomineralization in mice by alteration of the expression of kallikrein-related peptidase 4 (Klk4) during pH cycling process. FASEB J. 2023 Apr;37(4):e22861

TSS for Adgrf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr148101	Chr17:43053058-43053080 (-)	1 bp
Tssr148100	Chr17:43053036-43053053 (-)	25 bp
Tssr148099	Chr17:43053016-43053028 (-)	48 bp
Tssr148098	Chr17:43052943-43052976 (-)	110 bp
Tssr148097	Chr17:43052915-43052918 (-)	153 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24