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Kat7 Gene Detail
Summary
  • Symbol
    Kat7
  • Name
    K(lysine) acetyltransferase 7
  • Synonyms
    Hbo1, Hboa, MGC:56758, Myst2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182799
    NCBI Gene: 217127
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:95165085-95201072 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 59.01 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    971 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2182799
 protein coding gene Chr11:95162683-95201072 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018980
 protein coding gene Chr11:97465690-97501683 (-)
A/J MGP_AJ_G0018948
 protein coding gene Chr11:93536376-93572276 (-)
AKR/J MGP_AKRJ_G0018918
 protein coding gene Chr11:96426350-96471436 (-)
BALB/cJ MGP_BALBcJ_G0018921
 protein coding gene Chr11:94006887-94043188 (-)
C3H/HeJ MGP_C3HHeJ_G0018735
 protein coding gene Chr11:96551896-96589273 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019373
 protein coding gene Chr11:100529335-100569370 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017004
 protein coding gene Chr11:91020967-91057289 (-)
CAST/EiJ MGP_CASTEiJ_G0018289
 protein coding gene Chr11:97345797-97389725 (-)
CBA/J MGP_CBAJ_G0018706
 protein coding gene Chr11:104631336-104674737 (-)
DBA/2J MGP_DBA2J_G0018814
 protein coding gene Chr11:93108516-93144662 (-)
FVB/NJ MGP_FVBNJ_G0018803
 protein coding gene Chr11:92576630-92614057 (-)
LP/J MGP_LPJ_G0018884
 protein coding gene Chr11:98032132-98072263 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018830
 protein coding gene Chr11:104677307-104714680 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019413
 protein coding gene Chr11:96689647-96729944 (-)
PWK/PhJ MGP_PWKPhJ_G0018060
 protein coding gene Chr11:94027529-94068915 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017849
 protein coding gene Chr11:96374751-96412340 (-)
WSB/EiJ MGP_WSBEiJ_G0018338
 protein coding gene Chr11:96611273-96649404 (-)



Homology
more
  • Human Ortholog
    KAT7, lysine acetyltransferase 7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KAT7, lysine acetyltransferase 7
  • Synonyms
    HBO1, HBOA, MYST2, ZC2HC7
  • Links
    NCBI Gene ID: 11143
    neXtProt AC: NX_O95251
    UniProt: O95251

  • Chr Location
    17q21.33; chr17:49788624-49835026 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic growth arrest, incomplete embryo turning, disorganized yolk sac vascular plexus, and increased apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    91
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    774
  • Tissues
    51
  • cDNA Data
    17
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038909 Ensembl Gene Model | MGI Sequence Detail 35988 C57BL/6J ±  kb
    transcript ENSMUST00000249615 Ensembl | MGI Sequence Detail 3560 Not Applicable  
    polypeptide ENSMUSP00000159824 Ensembl | MGI Sequence Detail 637 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 17
      Primer pair 3
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 15
      Gene Ontology 12
      Phenotypes 20
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:332921 Kueh AJ, et al., Stem cell plasticity, acetylation of H3K14, and de novo gene activation rely on KAT7. Cell Rep. 2023 Jan 13;42(1):111980
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory