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Serpina3b Gene Detail
Summary
  • Symbol
    Serpina3b
  • Name
    serine (or cysteine) peptidase inhibitor, clade A, member 3B
  • Synonyms
    6A1, A030003A19Rik, alpha-1 antiproteinase, antitrypsin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182835
    NCBI Gene: 271047
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:104094255-104105804 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 53.40 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    719 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2182835
 protein coding gene Chr12:104094245-104105805 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020068
 protein coding gene Chr12:105885463-105897724 (+)
A/J MGP_AJ_G0020022
 protein coding gene Chr12:101894245-101905794 (+)
AKR/J MGP_AKRJ_G0019999
 protein coding gene Chr12:104754626-104766065 (+)
BALB/cJ MGP_BALBcJ_G0020008
 protein coding gene Chr12:102207261-102218700 (+)
C3H/HeJ MGP_C3HHeJ_G0019812
 protein coding gene Chr12:105260427-105271976 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020455
 protein coding gene Chr12:109199680-109211223 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018071
 protein coding gene Chr12:98574378-98584610 (+)
CAST/EiJ MGP_CASTEiJ_G0019352
 protein coding gene Chr12:100018317-100029872 (+)
CBA/J MGP_CBAJ_G0019778
 protein coding gene Chr12:113272812-113284251 (+)
DBA/2J MGP_DBA2J_G0019895
 protein coding gene Chr12:101329008-101341247 (+)
FVB/NJ MGP_FVBNJ_G0019881
 protein coding gene Chr12:100154564-100166415 (+)
LP/J MGP_LPJ_G0019970
 protein coding gene Chr12:105726879-105738428 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0020483
 protein coding gene Chr12:104239653-104251202 (+)
PWK/PhJ MGP_PWKPhJ_G0019116
 protein coding gene Chr12:95875273-95886751 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018916
 protein coding gene Chr12:98440235-98450892 (+)
WSB/EiJ MGP_WSBEiJ_G0019411
 protein coding gene Chr12:105110426-105127345 (+)



Homology
more
  • Human Ortholog
    SERPINA3, serpin family A member 3
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERPINA3, serpin family A member 3
  • Synonyms
    AACT, ACT, GIG24, GIG25
  • Links
    NCBI Gene ID: 12
    neXtProt AC: NX_P01011
    UniProt: P01011

  • Chr Location
    14q32.13; chr14:94612384-94624055 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human SERPINA3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000066364 Ensembl Gene Model | MGI Sequence Detail 11550 C57BL/6J ±  kb
transcript ENSMUST00000085052 Ensembl | MGI Sequence Detail 2070 Not Applicable  
polypeptide ENSMUSP00000082127 Ensembl | MGI Sequence Detail 420 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 1
Other
Accession IDs
less
MGI:3045329
References
more
  • Summaries
    All 24
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:25107 Inglis JD, et al., The murine Spi-2 proteinase inhibitor locus: a multigene family with a hypervariable reactive site domain. EMBO J. 1991 Feb;10(2):255-61
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory