About   Help   FAQ
Rxfp4 Gene Detail
Summary
  • Symbol
    Rxfp4
  • Name
    relaxin family peptide receptor 4
  • Synonyms
    Gpr100, Rln3r2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182926
    NCBI Gene: 242093
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr3:88559205-88560449 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 38.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    145 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2182926
 protein coding gene Chr3:88559081-88560489 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027405
 protein coding gene Chr3:88831079-88832323 (-)
A/J MGP_AJ_G0027369
 protein coding gene Chr3:85830710-85831954 (-)
AKR/J MGP_AKRJ_G0027333
 protein coding gene Chr3:87948525-87949769 (-)
BALB/cJ MGP_BALBcJ_G0027378
 protein coding gene Chr3:85915337-85916581 (-)
C3H/HeJ MGP_C3HHeJ_G0027120
 protein coding gene Chr3:88207243-88208487 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027824
 protein coding gene Chr3:92133102-92134346 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025176
 protein coding gene Chr3:81436229-81437631 (-)
CAST/EiJ MGP_CASTEiJ_G0026566
 protein coding gene Chr3:88443969-88445213 (-)
CBA/J MGP_CBAJ_G0027094
 protein coding gene Chr3:95299378-95300622 (-)
DBA/2J MGP_DBA2J_G0027232
 protein coding gene Chr3:85313126-85314370 (-)
FVB/NJ MGP_FVBNJ_G0027200
 protein coding gene Chr3:83583863-83585107 (-)
LP/J MGP_LPJ_G0027341
 protein coding gene Chr3:89843781-89845025 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027220
 protein coding gene Chr3:101506067-101507311 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027883
 protein coding gene Chr3:87695183-87696427 (-)
PWK/PhJ MGP_PWKPhJ_G0026300
 protein coding gene Chr3:85096298-85097543 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026119
 protein coding gene Chr3:86881079-86882323 (-)
WSB/EiJ MGP_WSBEiJ_G0026648
 protein coding gene Chr3:88050440-88051684 (-)



Homology
more
  • Human Ortholog
    RXFP4, relaxin family peptide/INSL5 receptor 4
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RXFP4, relaxin family peptide/INSL5 receptor 4
  • Synonyms
    GPCR142, GPR100, RLN3R2, RXFPR4
  • Links
    NCBI Gene ID: 339403
    neXtProt AC: NX_Q8TDU9
    UniProt: Q8TDU9

  • Chr Location
    1q22; chr1:155941638-155943087 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced refeeding responses after fasting, altered food preference, and reduced fat content.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    10
  • cDNA Data
    5
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049741 Ensembl Gene Model | MGI Sequence Detail 1245 C57BL/6J ±  kb
    transcript ENSMUST00000063119 Ensembl | MGI Sequence Detail 1245 Not Applicable  
    polypeptide ENSMUSP00000058732 Ensembl | MGI Sequence Detail 414 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 1
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory