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Sardh Gene Detail
Summary
  • Symbol
    Sardh
  • Name
    sarcosine dehydrogenase
  • Synonyms
    MGC:6279
  • Feature Type
    protein coding gene
  • IDs
    MGI:2183102
    NCBI Gene: 192166
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:27078405-27138344 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 19.31 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1808 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2183102
 protein coding gene Chr2:27078405-27138349 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025512
 protein coding gene Chr2:25164136-25225442 (-)
A/J MGP_AJ_G0025489
 protein coding gene Chr2:24214300-24274936 (-)
AKR/J MGP_AKRJ_G0025459
 protein coding gene Chr2:25008804-25068670 (-)
BALB/cJ MGP_BALBcJ_G0025485
 protein coding gene Chr2:24332591-24393803 (-)
C3H/HeJ MGP_C3HHeJ_G0025246
 protein coding gene Chr2:24942830-25005118 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025929
 protein coding gene Chr2:26014924-26076894 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023340
 protein coding gene Chr2:23047448-23106288 (-)
CAST/EiJ MGP_CASTEiJ_G0024709
 protein coding gene Chr2:24823393-24884044 (-)
CBA/J MGP_CBAJ_G0025224
 protein coding gene Chr2:26920404-26983472 (-)
DBA/2J MGP_DBA2J_G0025357
 protein coding gene Chr2:24035770-24095994 (-)
FVB/NJ MGP_FVBNJ_G0025319
 protein coding gene Chr2:23792843-23854892 (-)
LP/J MGP_LPJ_G0025443
 protein coding gene Chr2:25105265-25170795 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025350
 protein coding gene Chr2:26957603-27022244 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025988
 protein coding gene Chr2:24942519-25002321 (-)
PWK/PhJ MGP_PWKPhJ_G0024457
 protein coding gene Chr2:23826467-23887233 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024257
 protein coding gene Chr2:25086140-25150704 (-)
WSB/EiJ MGP_WSBEiJ_G0024778
 protein coding gene Chr2:25058873-25119553 (-)



Homology
more
  • Human Ortholog
    SARDH, sarcosine dehydrogenase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SARDH, sarcosine dehydrogenase
  • Synonyms
    BPR-2, DMGDHL1, SAR, SARD, SDH
  • Links
    NCBI Gene ID: 1757
    neXtProt AC: NX_Q9UL12
    UniProt: Q9UL12

  • Chr Location
    9q34.2; chr9:133659418-133739955 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SARDH associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele reduced body weight, impaired spatial working memory, reduced hippocampal sacosine and formaldehyde levels, and reduced NMDA currents.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    14
  • cDNA Data
    153
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 192166 NCBI Gene Model | MGI Sequence Detail 59940 C57BL/6J ±  kb
    transcript NM_138665 RefSeq | MGI Sequence Detail 4573 C57BL/6  
    polypeptide Q99LB7 UniProt | EBI | MGI Sequence Detail 919 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000014456 sarcosine dehydrogenase, mitochondrial
      (term hierarchy)
    • EC
      1.5.8.3
    • InterPro Domains
      IPR006222 Aminomethyltransferase, folate-binding domain
      IPR028896 Aminomethyltransferase-like
      IPR006076 FAD dependent oxidoreductase
      IPR032503 FAD dependent oxidoreductase, central domain
      IPR036188 FAD/NAD(P)-binding domain superfamily
      IPR013977 Glycine cleavage T-protein, C-terminal barrel domain
      IPR029043 Glycine cleavage T-protein/YgfZ, C-terminal
      IPR027266 GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1
    • GlyGen
      Q99LB7 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 155
      cDNA 153
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:37 Harding CO, et al., sar: a genetic mouse model for human sarcosinemia generated by ethylnitrosourea mutagenesis. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2644-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory