Nadk MGI Mouse Gene Detail - MGI:2183149

Symbol

Nadk
Name

NAD kinase
Synonyms

4432404C02Rik, MGC:7589

Feature Type

protein coding gene
IDs

MGI:2183149
NCBI Gene: 192185
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr4:155646838-155675458 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 86.44 cM
Mapping Data

2 experiments

SNPs within 2kb

936 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2183149	protein coding gene	Chr4:155646835-155675458 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029216	protein coding gene	Chr4:159904803-159933884 (+)
A/J	MGP_AJ_G0029181	protein coding gene	Chr4:153182146-153210650 (+)
AKR/J	MGP_AKRJ_G0029129	protein coding gene	Chr4:157345270-157373684 (+)
BALB/cJ	MGP_BALBcJ_G0029197	protein coding gene	Chr4:153655437-153683822 (+)
C3H/HeJ	MGP_C3HHeJ_G0028918	protein coding gene	Chr4:157893258-157921688 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029646	protein coding gene	Chr4:165587201-165617041 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026892	protein coding gene	Chr4:145470927-145500361 (+)
CAST/EiJ	MGP_CASTEiJ_G0028331	protein coding gene	Chr4:155333601-155369063 (+)
CBA/J	MGP_CBAJ_G0028880	protein coding gene	Chr4:170587416-170623411 (+)
DBA/2J	MGP_DBA2J_G0029029	protein coding gene	Chr4:153201791-153230120 (+)
FVB/NJ	MGP_FVBNJ_G0028993	protein coding gene	Chr4:152441814-152471511 (+)
LP/J	MGP_LPJ_G0029119	protein coding gene	Chr4:159823030-159854539 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029020	protein coding gene	Chr4:173405029-173433424 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029678	protein coding gene	Chr4:157969451-157998896 (+)
PWK/PhJ	MGP_PWKPhJ_G0028051	protein coding gene	Chr4:149339784-149370287 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027885	protein coding gene	Chr4:152222658-152258178 (+)
WSB/EiJ	MGP_WSBEiJ_G0028411	protein coding gene	Chr4:158141369-158174255 (+)

Human Ortholog

NADK, NAD kinase

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NADK, NAD kinase
Synonyms

dJ283E3.1, NADK1
Links

HGNC:29831

NCBI Gene ID: 65220

neXtProt AC: NX_O95544

UniProt: O95544
Chr Location

1p36.33; chr1:1751232-1780514 (-) GRCh38

MGI Vertebrate Homology

Nadk stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NADK
Gene Tree

Nadk

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Endonuclease-mediated

6
Gene trapped

21
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

53 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

12
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

251
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nadk

ZFIN nadka, nadkb

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All Sequences

90
RefSeq

12
UniProt

8
CCDS

CCDS19031.1

Ensembl

ENSMUSG00000029063 (Evidence)
NCBI Gene

192185

			Length	Strain/Species	Flank
genomic	192185	NCBI Gene Model \| MGI Sequence Detail	28621	C57BL/6J	± kb
transcript	NM_001159637	RefSeq \| MGI Sequence Detail	3053	C57BL/6
polypeptide	P58058	UniProt \| EBI \| MGI Sequence Detail	439	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000010955 NAD kinase

(term hierarchy)
EC

2.7.1.23
InterPro Domains

IPR017437 ATP-NAD kinase, PpnK-type, C-terminal

IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal

IPR002504 NAD kinase

IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily

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All nucleic 252

cDNA 252

Microarray probesets 4

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MGI:1918027

Summaries

All 41

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nadk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40667	Chr4:155646805-155646870 (+)	0 bp
Tssr40668	Chr4:155646871-155646882 (+)	39 bp
Tssr1399	Chr4:155647721-155647731 (+)	888 bp
Tssr40669	Chr4:155647764-155647778 (+)	933 bp
Tssr40670	Chr4:155648189-155648200 (+)	1,357 bp
Tssr40671	Chr4:155648255-155648322 (+)	1,451 bp
Tssr40672	Chr4:155661588-155661621 (+)	14,767 bp
Tssr40673	Chr4:155661912-155661923 (+)	15,080 bp
Tssr40674	Chr4:155666933-155666946 (+)	20,102 bp
Tssr40675	Chr4:155666978-155667004 (+)	20,153 bp
Tssr40676	Chr4:155667192-155667201 (+)	20,359 bp
Tssr40677	Chr4:155667218-155667229 (+)	20,386 bp
Tssr40678	Chr4:155671807-155671821 (+)	24,976 bp
Tssr40679	Chr4:155672365-155672377 (+)	25,533 bp
Tssr40680	Chr4:155674192-155674208 (+)	27,362 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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