Med9 MGI Mouse Gene Detail - MGI:2183151 - mediator complex subunit 9

Symbol

Med9
Name

mediator complex subunit 9
Synonyms

Med25, MED25, MGC:30366

Feature Type

protein coding gene
IDs

MGI:2183151
NCBI Gene: 192191
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr11:59839032-59853031 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 37.81 cM
Mapping Data

3 experiments

SNPs within 2kb

392 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2183151	protein coding gene	Chr11:59839032-59854132 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018409	protein coding gene	Chr11:59805266-59819260 (+)
A/J	MGP_AJ_G0018378	protein coding gene	Chr11:57533288-57545777 (+)
AKR/J	MGP_AKRJ_G0018348	protein coding gene	Chr11:59449361-59463496 (+)
BALB/cJ	MGP_BALBcJ_G0018349	protein coding gene	Chr11:57875424-57889403 (+)
C3H/HeJ	MGP_C3HHeJ_G0018162	protein coding gene	Chr11:59328351-59340840 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018801	protein coding gene	Chr11:61704627-61720105 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016447	protein coding gene	Chr11:54776614-54790866 (+)
CAST/EiJ	MGP_CASTEiJ_G0017719	protein coding gene	Chr11:59461149-59473412 (+)
CBA/J	MGP_CBAJ_G0018136	protein coding gene	Chr11:64406302-64418791 (+)
DBA/2J	MGP_DBA2J_G0018245	protein coding gene	Chr11:57189786-57203976 (+)
FVB/NJ	MGP_FVBNJ_G0018236	protein coding gene	Chr11:56849811-56863815 (+)
LP/J	MGP_LPJ_G0018318	protein coding gene	Chr11:60409024-60423025 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018260	protein coding gene	Chr11:65484402-65498436 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018842	protein coding gene	Chr11:59483160-59496926 (+)
PWK/PhJ	MGP_PWKPhJ_G0017490	protein coding gene	Chr11:57790853-57803370 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017282	protein coding gene	Chr11:59274666-59291130 (+)
WSB/EiJ	MGP_WSBEiJ_G0017770	protein coding gene	Chr11:59154445-59168444 (+)

Human Ortholog

MED9, mediator complex subunit 9

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MED9, mediator complex subunit 9
Synonyms

MED25
Links

HGNC:25487

NCBI Gene ID: 55090

neXtProt AC: NX_Q9NWA0

UniProt: Q9NWA0
Chr Location

17p11.2; chr17:17476994-17493221 (+) GRCh38

MGI Vertebrate Homology

Med9 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MED9
Gene Tree

Med9

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References

3 with disease annotations

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Phenotype Summary

19 phenotype references

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

7
Targeted

6
Genomic Mutations

4 involving Med9
Find Mice (IMSR)

11 strains or lines available

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All GO Annotations

11
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

3

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase med9

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All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS24780.1

Ensembl

ENSMUSG00000061650 (Evidence)
NCBI Gene

192191

			Length	Strain/Species	Flank
genomic	ENSMUSG00000061650	Ensembl Gene Model \| MGI Sequence Detail	14000	C57BL/6J	± kb
transcript	ENSMUST00000081980	Ensembl \| MGI Sequence Detail	1920	Not Applicable
polypeptide	ENSMUSP00000080641	Ensembl \| MGI Sequence Detail	142	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010308 mediator of RNA polymerase II transcription subunit 9

(term hierarchy)
PDB

6W1S, 8T1I, 8T1L
InterPro Domains

IPR037212 Mediator complex, subunit Med7/Med21-like

IPR011425 Mediator of RNA polymerase II transcription subunit 9

IPR039242 Mediator of RNA polymerase II transcription subunit 9, metazoan

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All nucleic 5

Genomic 1

cDNA 3

Primer pair 1

Microarray probesets 3

Summaries

All 43

Diseases 3

Gene Ontology 6

Phenotypes 19
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:347774 Kolonay DW, et al., Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease. Front Cell Dev Biol. 2024;12:1331563

TSS for Med9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101871	Chr11:59839035-59839087 (+)	29 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24