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Agap3 Gene Detail
Summary
  • Symbol
    Agap3
  • Name
    ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
  • Synonyms
    Centg3, Crag, MGC:37541, MRIP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2183446
    NCBI Gene: 213990
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:24657175-24707045 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 11.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1084 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2183446
 protein coding gene Chr5:24657175-24707045 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029346
 protein coding gene Chr5:22184166-22237771 (+)
A/J MGP_AJ_G0029312
 protein coding gene Chr5:21424813-21475625 (+)
AKR/J MGP_AKRJ_G0029263
 protein coding gene Chr5:22286445-22338118 (+)
BALB/cJ MGP_BALBcJ_G0029323
 protein coding gene Chr5:21938068-21989706 (+)
C3H/HeJ MGP_C3HHeJ_G0029043
 protein coding gene Chr5:22401174-22454717 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029776
 protein coding gene Chr5:23673671-23731790 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027014
 protein coding gene Chr5:19367457-19417413 (+)
CAST/EiJ MGP_CASTEiJ_G0028455
 protein coding gene Chr5:21574566-21631038 (+)
CBA/J MGP_CBAJ_G0029010
 protein coding gene Chr5:24063110-24116999 (+)
DBA/2J MGP_DBA2J_G0029161
 protein coding gene Chr5:21718374-21768946 (+)
FVB/NJ MGP_FVBNJ_G0029119
 protein coding gene Chr5:21087272-21139612 (+)
LP/J MGP_LPJ_G0029245
 protein coding gene Chr5:22585618-22638356 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029148
 protein coding gene Chr5:25184600-25235171 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029810
 protein coding gene Chr5:21930393-21987577 (+)
PWK/PhJ MGP_PWKPhJ_G0028179
 protein coding gene Chr5:20794778-20849058 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028010
 protein coding gene Chr5:21284261-21335932 (+)
WSB/EiJ MGP_WSBEiJ_G0028535
 protein coding gene Chr5:21998804-22057180 (+)



Homology
more
  • Human Ortholog
    AGAP3, ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGAP3, ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
  • Synonyms
    AGAP-3, CENTG3, cnt-g3, CRAG, MRIP-1
  • Links
    NCBI Gene ID: 116988
    neXtProt AC: NX_Q96P47
    UniProt: Q96P47

  • Chr Location
    7q36.1; chr7:151085831-151144436 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit postnatal lethality and hyperactivity. Mice homozygous for a conditional allele activated in the dorsal forebrain exhibit immature dentate gyrus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    74
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 213990 NCBI Gene Model | MGI Sequence Detail 49871 C57BL/6J ±  kb
    transcript NM_139153 RefSeq | MGI Sequence Detail 3207 C57BL/6  
    polypeptide Q8VHH5 UniProt | EBI | MGI Sequence Detail 910 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000003817 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3
      (term hierarchy)
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR038508 ArfGAP domain superfamily
      IPR037278 ARFGAP/RecO-like zinc finger
      IPR051282 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein
      IPR001164 Arf GTPase activating protein
      IPR011993 PH-like domain superfamily
      IPR001849 Pleckstrin homology domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR001806 Small GTPase
    • GlyGen
      Q8VHH5 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 76
      cDNA 74
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141107
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 3
      Phenotypes 18
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory