Uts2r MGI Mouse Gene Detail - MGI:2183450

Symbol

Uts2r
Name

urotensin 2 receptor
Synonyms

Gpr14, urotensin II receptor, UTR2

Feature Type

protein coding gene
IDs

MGI:2183450
NCBI Gene: 217369
Alliance

gene page

Sequence Map

Chr11:121051097-121052799 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 85.02 cM
Mapping Data

1 experiment

SNPs within 2kb

135 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2183450	protein coding gene	Chr11:121051097-121052799 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019540	protein coding gene	Chr11:125694357-125696059 (+)
A/J	MGP_AJ_G0019507	protein coding gene	Chr11:120084497-120086199 (+)
AKR/J	MGP_AKRJ_G0019477	protein coding gene	Chr11:123719564-123721266 (+)
BALB/cJ	MGP_BALBcJ_G0019482	protein coding gene	Chr11:120450060-120451762 (+)
C3H/HeJ	MGP_C3HHeJ_G0019288	protein coding gene	Chr11:124043061-124044763 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019931	protein coding gene	Chr11:129511591-129513293 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017556	protein coding gene	Chr11:117063096-117064804 (+)
CAST/EiJ	MGP_CASTEiJ_G0018842	protein coding gene	Chr11:125543008-125544710 (+)
CBA/J	MGP_CBAJ_G0019259	protein coding gene	Chr11:134544855-134546557 (+)
DBA/2J	MGP_DBA2J_G0019372	protein coding gene	Chr11:119449153-119450855 (+)
FVB/NJ	MGP_FVBNJ_G0019363	protein coding gene	Chr11:119166076-119167778 (+)
LP/J	MGP_LPJ_G0019443	protein coding gene	Chr11:125974668-125976370 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019396	protein coding gene	Chr11:133357919-133359621 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019970	protein coding gene	Chr11:124394971-124396673 (+)
PWK/PhJ	MGP_PWKPhJ_G0018609	protein coding gene	Chr11:120894026-120895728 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018400	protein coding gene	Chr11:124151656-124153358 (+)
WSB/EiJ	MGP_WSBEiJ_G0018895	protein coding gene	Chr11:124371092-124372794 (+)

Human Ortholog

UTS2R, urotensin 2 receptor

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UTS2R, urotensin 2 receptor
Synonyms

GPR14, UR-2-R, UTR, UTR2
Links

HGNC:4468

NCBI Gene ID: 2837

neXtProt AC: NX_Q9UKP6

UniProt: Q9UKP6
Chr Location

17q25.3; chr17:82371765-82377458 (+) GRCh38

MGI Vertebrate Homology

Uts2r stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: UTS2R
Gene Tree

Uts2r

less

Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele display a selective loss of urotensin-II contractile activity in isolated aortae.

less

All GO Annotations

22
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

6

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

31
RefSeq

2
UniProt

2
CCDS

CCDS25769.1

Ensembl

ENSMUSG00000039321 (Evidence)
NCBI Gene

217369

			Length	Strain/Species	Flank
genomic	217369	NCBI Gene Model \| MGI Sequence Detail	1703	C57BL/6J	± kb
transcript	NM_145440	RefSeq \| MGI Sequence Detail	1703	BALB/c
polypeptide	Q8VIH9	UniProt \| EBI \| MGI Sequence Detail	385	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000001561 urotensin-2 receptor

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR000670 Urotensin II receptor
GlyGen

Q8VIH9 2 sites

less

All nucleic 6

cDNA 6

Microarray probesets 3

Summaries

All 39

Gene Ontology 5

Phenotypes 11
Earliest

J:103118 Behm DJ, et al., Deletion of the UT receptor gene results in the selective loss of urotensin-II contractile activity in aortae isolated from UT receptor knockout mice. Br J Pharmacol. 2003 May;139(2):464-72
Latest

J:334999 Yin L, et al., Urotensin receptor acts as a novel target for ameliorating fasting-induced skeletal muscle atrophy. Pharmacol Res. 2022 Nov;185:106468

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24