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Cntnap4 Gene Detail
Summary
  • Symbol
    Cntnap4
  • Name
    contactin associated protein-like 4
  • Synonyms
    Caspr4, E130114F09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2183572
    NCBI Gene: 170571
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:113296675-113609349 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 58.70 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8067 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2183572
 protein coding gene Chr8:113296523-113609349 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034154
 protein coding gene Chr8:115444701-115766867 (+)
A/J MGP_AJ_G0034134
 protein coding gene Chr8:110727608-111025961 (+)
AKR/J MGP_AKRJ_G0034061
 protein coding gene Chr8:113988546-114308834 (+)
BALB/cJ MGP_BALBcJ_G0034128
 protein coding gene Chr8:110928152-111245132 (+)
C3H/HeJ MGP_C3HHeJ_G0033839
 protein coding gene Chr8:114695717-115011665 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034648
 protein coding gene Chr8:119474785-119811226 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031590
 protein coding gene Chr8:103786998-104077570 (+)
CAST/EiJ MGP_CASTEiJ_G0033166
 protein coding gene Chr8:114369222-114683725 (+)
CBA/J MGP_CBAJ_G0033812
 protein coding gene Chr8:123608732-123963365 (+)
DBA/2J MGP_DBA2J_G0033968
 protein coding gene Chr8:109996476-110301570 (+)
FVB/NJ MGP_FVBNJ_G0033911
 protein coding gene Chr8:108973003-109287300 (+)
LP/J MGP_LPJ_G0034057
 protein coding gene Chr8:115593479-115920901 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033958
 protein coding gene Chr8:126405048-126768932 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034666
 protein coding gene Chr8:113993226-114314518 (+)
PWK/PhJ MGP_PWKPhJ_G0032868
 protein coding gene Chr8:109635463-109934964 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032708
 protein coding gene Chr8:112645444-112948913 (+)
WSB/EiJ MGP_WSBEiJ_G0033282
 protein coding gene Chr8:114688879-115016651 (+)



Homology
more
  • Human Ortholog
    CNTNAP4, contactin associated protein family member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNTNAP4, contactin associated protein family member 4
  • Synonyms
    CASPR4
  • Links
    NCBI Gene ID: 85445
    neXtProt AC: NX_Q9C0A0
    UniProt: Q9C0A0

  • Chr Location
    16q23.1; chr16:76277278-76560757 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knock-out mice show increased midbrain dopaminergic release in the nucleus accumbens, synaptic defects, impaired sensory-motor gating, and increased grooming behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    20
  • cDNA Data
    7
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031772 Ensembl Gene Model | MGI Sequence Detail 312675 C57BL/6J ±  kb
    transcript ENSMUST00000034225 Ensembl | MGI Sequence Detail 4848 Not Applicable  
    polypeptide ENSMUSP00000034225 Ensembl | MGI Sequence Detail 1310 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000005676 contactin-associated protein-like 4
      (term hierarchy)
    • InterPro Domains
      IPR000421 Coagulation factor 5/8 C-terminal domain
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR000742 EGF-like domain
      IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
      IPR036056 Fibrinogen-like, C-terminal
      IPR008979 Galactose-binding-like domain superfamily
      IPR001791 Laminin G domain
      IPR050372 Neurexin-related cell adhesion and synaptic protein
    • GlyGen
      Q99P47 14 sites, 13 N-linked glycans (7 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2443222
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:77463 Spiegel I, et al., Caspr3 and caspr4, two novel members of the caspr family are expressed in the nervous system and interact with PDZ domains. Mol Cell Neurosci. 2002 Jun;20(2):283-97
    • Latest
      J:335251 Zhang W, et al., Cntnap4 partial deficiency exacerbates alpha-synuclein pathology through astrocyte-microglia C3-C3aR pathway. Cell Death Dis. 2023 Apr 22;14(4):285
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory