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Nav2 Gene Detail
Summary
  • Symbol
    Nav2
  • Name
    neuron navigator 2
  • Synonyms
    5330421F07Rik, HELAD1, mKIAA3015, POMFIL2, Rainb1, RAINB2, Unc53H2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2183691
    NCBI Gene: 78286
  • Alliance
    gene page
  • Transcription Start Sites
    56 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:48608796-49259838 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 31.23 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    20998 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2183691
 protein coding gene Chr7:48558464-49259838 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032297
 protein coding gene Chr7:49517240-50268820 (+)
A/J MGP_AJ_G0032276
 protein coding gene Chr7:48821276-49524903 (+)
AKR/J MGP_AKRJ_G0032212
 protein coding gene Chr7:49966349-50701992 (+)
BALB/cJ MGP_BALBcJ_G0032288
 protein coding gene Chr7:48467793-49178842 (+)
C3H/HeJ MGP_C3HHeJ_G0032001
 protein coding gene Chr7:50338743-51075090 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032781
 protein coding gene Chr7:51821023-52574898 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029787
 protein coding gene Chr7:51996623-52701531 (+)
CAST/EiJ MGP_CASTEiJ_G0031329
 protein coding gene Chr7:41722527-42482466 (+)
CBA/J MGP_CBAJ_G0031966
 protein coding gene Chr7:53556616-54337228 (+)
DBA/2J MGP_DBA2J_G0032123
 protein coding gene Chr7:48030725-48750089 (+)
FVB/NJ MGP_FVBNJ_G0032077
 protein coding gene Chr7:47960003-48680167 (+)
LP/J MGP_LPJ_G0032204
 protein coding gene Chr7:50484267-51223427 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032114
 protein coding gene Chr7:52680023-53460743 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032798
 protein coding gene Chr7:48945064-49683287 (+)
PWK/PhJ MGP_PWKPhJ_G0031049
 protein coding gene Chr7:41367947-42091858 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030890
 protein coding gene Chr7:37115979-37861276 (+)
WSB/EiJ MGP_WSBEiJ_G0031447
 protein coding gene Chr7:49602462-50344144 (+)



Homology
more
  • Human Ortholog
    NAV2, neuron navigator 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NAV2, neuron navigator 2
  • Synonyms
    HELAD1, POMFIL2, RAINB1, STEERIN2, UNC53H2
  • Links
    NCBI Gene ID: 89797
    neXtProt AC: NX_Q8IVL1
    UniProt: Q8IVL1

  • Chr Location
    11p15.1; chr11:19345236-20121601 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display impaired olfaction and hearing, increased latency in a hot plate test, degeneration of the optic nerve, decreased exploration in new environments, and weight loss.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1160
  • Tissues
    141
  • cDNA Data
    25
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 78286 NCBI Gene Model | MGI Sequence Detail 651043 C57BL/6J ±  kb
    transcript NM_175272 RefSeq | MGI Sequence Detail 11332 C57BL/6  
    polypeptide NP_780481 RefSeq | MGI Sequence Detail 2432 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 25
      Primer pair 12
      Other 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1925536, MGI:2142165, MGI:3664665
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 13
      Gene Ontology 5
      Phenotypes 16
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory