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Fgd4 Gene Detail
Summary
  • Symbol
    Fgd4
  • Name
    FYVE, RhoGEF and PH domain containing 4
  • Synonyms
    9330209B17Rik, Frabin, Frabin-alpha, Frabin-beta, Frabin-gamma, ZFYVE6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2183747
    NCBI Gene: 224014
  • Alliance
    gene page
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:16234774-16418400 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 10.18 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3880 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2183747
 protein coding gene Chr16:16234774-16418413 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022558
 protein coding gene Chr16:13522811-13699423 (-)
A/J MGP_AJ_G0022519
 protein coding gene Chr16:12824821-13009172 (-)
AKR/J MGP_AKRJ_G0022496
 protein coding gene Chr16:13342116-13530973 (-)
BALB/cJ MGP_BALBcJ_G0022524
 protein coding gene Chr16:12984353-13165748 (-)
C3H/HeJ MGP_C3HHeJ_G0022291
 protein coding gene Chr16:13436963-13619389 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022973
 protein coding gene Chr16:13695655-13883867 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020493
 protein coding gene Chr16:12904135-13071328 (-)
CAST/EiJ MGP_CASTEiJ_G0021818
 protein coding gene Chr16:13379201-13561302 (-)
CBA/J MGP_CBAJ_G0022260
 protein coding gene Chr16:14320932-14528963 (-)
DBA/2J MGP_DBA2J_G0022392
 protein coding gene Chr16:12769723-12948039 (-)
FVB/NJ MGP_FVBNJ_G0022367
 protein coding gene Chr16:12810192-12980447 (-)
LP/J MGP_LPJ_G0022459
 protein coding gene Chr16:13311023-13493848 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022389
 protein coding gene Chr16:14019691-14239239 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022986
 protein coding gene Chr16:13282565-13457460 (-)
PWK/PhJ MGP_PWKPhJ_G0021560
 protein coding gene Chr16:13000658-13177214 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021388
 protein coding gene Chr16:13269955-13480538 (-)
WSB/EiJ MGP_WSBEiJ_G0021866
 protein coding gene Chr16:13281424-13473773 (-)



Homology
more
  • Human Ortholog
    FGD4, FYVE, RhoGEF and PH domain containing 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGD4, FYVE, RhoGEF and PH domain containing 4
  • Synonyms
    CMT4H, FRABP, ZFYVE6
  • Links
    NCBI Gene ID: 121512
    neXtProt AC: NX_Q96M96
    UniProt: Q96M96

  • Chr Location
    12p11.21; chr12:32399558-32646050 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fgd4 mouse models; 1 with human FGD4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 5 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display dysmyelination in early peripheral nerve development, followed by severe myelin abnormalities, demyelinationn, nervous system electrophysiological deficits, and decreased grip strength at later stages.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    821
  • Tissues
    19
  • cDNA Data
    15
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 224014 NCBI Gene Model | MGI Sequence Detail 183627 C57BL/6J ±  kb
    transcript NM_001301817 RefSeq | MGI Sequence Detail 8423 C57BL/6  
    polypeptide Q91ZT5 UniProt | EBI | MGI Sequence Detail 766 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 1
      cDNA 17

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2442956
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:78214 Obaishi H, et al., Frabin, a novel FGD1-related actin filament-binding protein capable of changing cell shape and activating c-Jun N-terminal kinase. J Biol Chem. 1998 Jul 24;273(30):18697-700
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory