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Trhde Gene Detail
Summary
  • Symbol
    Trhde
  • Name
    TRH-degrading enzyme
  • Synonyms
    9330155P21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384311
    NCBI Gene: 237553
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:114234725-114638207 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 61.59 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    12828 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384311
 protein coding gene Chr10:114234725-114638212 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017732
 protein coding gene Chr10:117048661-117465327 (-)
A/J MGP_AJ_G0017708
 protein coding gene Chr10:112557198-112970456 (-)
AKR/J MGP_AKRJ_G0017670
 protein coding gene Chr10:115867352-116275874 (-)
BALB/cJ MGP_BALBcJ_G0017671
 protein coding gene Chr10:112959778-113365071 (-)
C3H/HeJ MGP_C3HHeJ_G0017496
 protein coding gene Chr10:116037904-116463386 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018128
 protein coding gene Chr10:121119812-121543030 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015808
 protein coding gene Chr10:107221047-107622764 (-)
CAST/EiJ MGP_CASTEiJ_G0017058
 protein coding gene Chr10:116244889-116684791 (-)
CBA/J MGP_CBAJ_G0017465
 protein coding gene Chr10:125876512-126294868 (-)
DBA/2J MGP_DBA2J_G0017570
 protein coding gene Chr10:111727129-112126181 (-)
FVB/NJ MGP_FVBNJ_G0017565
 protein coding gene Chr10:110655438-111066950 (-)
LP/J MGP_LPJ_G0017645
 protein coding gene Chr10:117651151-118071735 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017594
 protein coding gene Chr10:128818685-129283702 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018166
 protein coding gene Chr10:115840738-116261525 (-)
PWK/PhJ MGP_PWKPhJ_G0016840
 protein coding gene Chr10:111785379-112200482 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016630
 protein coding gene Chr10:114632317-115071949 (-)
WSB/EiJ MGP_WSBEiJ_G0017118
 protein coding gene Chr10:116034052-116449855 (-)



Homology
more
  • Human Ortholog
    TRHDE, thyrotropin releasing hormone degrading enzyme
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRHDE, thyrotropin releasing hormone degrading enzyme
  • Synonyms
    PAP-II, PGPEP2, TRH-DE
  • Links
    NCBI Gene ID: 29953
    neXtProt AC: NX_Q9UKU6
    UniProt: Q9UKU6

  • Chr Location
    12q21.1; chr12:72087266-72670758 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    4
  • cDNA Data
    12
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 237553 NCBI Gene Model | MGI Sequence Detail 403483 C57BL/6J ±  kb
transcript NM_146241 RefSeq | MGI Sequence Detail 6655 C57BL/6  
polypeptide Q8K093 UniProt | EBI | MGI Sequence Detail 1066 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000016636 thyrotropin-releasing hormone-degrading ectoenzyme
    (term hierarchy)
  • EC
    3.4.11.-, 3.4.19.6
  • InterPro Domains
    IPR045357 Aminopeptidase N-like , N-terminal domain
    IPR042097 Aminopeptidase N-like , N-terminal domain superfamliy
    IPR034016 Aminopeptidase N-type
    IPR024571 ERAP1-like C-terminal domain
    IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
    IPR050344 Peptidase M1 family aminopeptidases
    IPR014782 Peptidase M1, membrane alanine aminopeptidase
    IPR027268 Peptidase M4/M1, CTD superfamily
  • GlyGen
    Q8K093 18 sites, 5 N-linked glycans (5 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 2
Other
Accession IDs
less
MGI:2444030
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory