B3gnt7 MGI Mouse Gene Detail - MGI:2384394 - UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7

Symbol

B3gnt7
Name

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
Synonyms

beta-3GnT7, C330001H22Rik

Feature Type

protein coding gene
IDs

MGI:2384394
NCBI Gene: 227327
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:86230943-86235027 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 43.94 cM
Mapping Data

3 experiments

SNPs within 2kb

135 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384394	protein coding gene	Chr1:86230554-86235027 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016245	protein coding gene	Chr1:87552640-87557112 (+)
A/J	MGP_AJ_G0016226	protein coding gene	Chr1:84315913-84320385 (+)
AKR/J	MGP_AKRJ_G0016187	protein coding gene	Chr1:86764721-86769194 (+)
BALB/cJ	MGP_BALBcJ_G0016183	protein coding gene	Chr1:84426562-84431035 (+)
C3H/HeJ	MGP_C3HHeJ_G0016011	protein coding gene	Chr1:87009856-87014328 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016639	protein coding gene	Chr1:90886034-90890507 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014361	protein coding gene	Chr1:78809493-78813948 (+)
CAST/EiJ	MGP_CASTEiJ_G0015596	protein coding gene	Chr1:86249448-86253923 (+)
CBA/J	MGP_CBAJ_G0015987	protein coding gene	Chr1:93705408-93709881 (+)
DBA/2J	MGP_DBA2J_G0016090	protein coding gene	Chr1:83622134-83626610 (+)
FVB/NJ	MGP_FVBNJ_G0016089	protein coding gene	Chr1:82671760-82676232 (+)
LP/J	MGP_LPJ_G0016161	protein coding gene	Chr1:88659588-88664060 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016115	protein coding gene	Chr1:96979898-96984371 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016682	protein coding gene	Chr1:86888888-86893360 (+)
PWK/PhJ	MGP_PWKPhJ_G0015383	protein coding gene	Chr1:82907915-82912388 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015163	protein coding gene	Chr1:85850697-85855185 (+)
WSB/EiJ	MGP_WSBEiJ_G0015660	protein coding gene	Chr1:86531915-86536389 (+)

Human Ortholog

B3GNT7, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

B3GNT7, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
Synonyms

beta3GnT7
Links

HGNC:18811

NCBI Gene ID: 93010

neXtProt AC: NX_Q8NFL0

UniProt: Q8NFL0
Chr Location

2q37.1; chr2:231395671-231408799 (+) GRCh38

MGI Vertebrate Homology

B3gnt7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: B3GNT7
Gene Tree

B3gnt7

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Chemically induced (other)

1
Gene trapped

21
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving B3gnt7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased stroma and total cornea thickness.

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All GO Annotations

13
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

845
Tissues

111
cDNA Data

64
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase b3gnt7

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All Sequences

46
RefSeq

2
UniProt

3
CCDS

CCDS35645.1

Ensembl

ENSMUSG00000079445 (Evidence)
NCBI Gene

227327

			Length	Strain/Species	Flank
genomic	227327	NCBI Gene Model \| MGI Sequence Detail	4085	C57BL/6J	± kb
transcript	NM_145222	RefSeq \| MGI Sequence Detail	2608	C57BL/6
polypeptide	Q8K0J2	UniProt \| EBI \| MGI Sequence Detail	397	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004597 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7

(term hierarchy)
EC

2.4.1.-
InterPro Domains

IPR002659 Glycosyl transferase, family 31
GlyGen

Q8K0J2 4 sites

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All nucleic 64

cDNA 64

Microarray probesets 3

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MGI:2443054

Summaries

All 42

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 15
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for B3gnt7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7735	Chr1:86230947-86230961 (+)	11 bp
Tssr7736	Chr1:86231159-86231168 (+)	221 bp
Tssr7737	Chr1:86231175-86231204 (+)	247 bp
Tssr7738	Chr1:86231211-86231225 (+)	275 bp
Tssr7739	Chr1:86234499-86234524 (+)	3,569 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24