Il27 MGI Mouse Gene Detail - MGI:2384409

Symbol

Il27
Name

interleukin 27
Synonyms

IL-27, IL-27p28, Il30, p28

Feature Type

protein coding gene
IDs

MGI:2384409
NCBI Gene: 246779
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr7:126188182-126194113 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 69.18 cM
Mapping Data

1 experiment

SNPs within 2kb

197 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384409	protein coding gene	Chr7:126188181-126194197 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032988	protein coding gene	Chr7:130872282-130878216 (-)
A/J	MGP_AJ_G0032971	protein coding gene	Chr7:127409681-127415607 (-)
AKR/J	MGP_AKRJ_G0032903	protein coding gene	Chr7:130632471-130638397 (-)
BALB/cJ	MGP_BALBcJ_G0032976	protein coding gene	Chr7:127067160-127073091 (-)
C3H/HeJ	MGP_C3HHeJ_G0032686	protein coding gene	Chr7:130562188-130568105 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033482	protein coding gene	Chr7:135962378-135968324 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030454	protein coding gene	Chr7:128599363-128605540 (-)
CAST/EiJ	MGP_CASTEiJ_G0032014	protein coding gene	Chr7:122355824-122361566 (-)
CBA/J	MGP_CBAJ_G0032659	protein coding gene	Chr7:140534053-140539998 (-)
DBA/2J	MGP_DBA2J_G0032811	protein coding gene	Chr7:125385643-125391572 (-)
FVB/NJ	MGP_FVBNJ_G0032764	protein coding gene	Chr7:125235347-125241982 (-)
LP/J	MGP_LPJ_G0032905	protein coding gene	Chr7:132337085-132343008 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032796	protein coding gene	Chr7:141722152-141728107 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033501	protein coding gene	Chr7:129649088-129654975 (-)
PWK/PhJ	MGP_PWKPhJ_G0031722	protein coding gene	Chr7:118373716-118379775 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031568	protein coding gene	Chr7:116477690-116483631 (-)
WSB/EiJ	MGP_WSBEiJ_G0032127	protein coding gene	Chr7:130616521-130622446 (-)

Human Ortholog

IL27, interleukin 27

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL27, interleukin 27
Synonyms

IL-27, IL-27A, IL27A, IL27p28, IL30, p28
Links

HGNC:19157

NCBI Gene ID: 246778

neXtProt AC: NX_Q8NEV9

UniProt: Q8NEV9
Chr Location

16p12.1-p11.2; chr16:28499362-28512051 (-) GRCh38

MGI Vertebrate Homology

Il27 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: IL27
Gene Tree

Il27

Diseases

3 with human IL27 associations

				Human Disease	Mouse Models
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				chronic obstructive pulmonary disease IDs chronic obstructive pulmonary disease DOID:3083 DOID:11500 DOID:6144 EFO:0000341 ICD10CM:J44.9 MESH:D029424 NCI:C3199 OMIM:606963 UMLS_CUI:C0024117
				pulmonary tuberculosis IDs pulmonary tuberculosis DOID:2957 ICD10CM:A15 ICD9CM:011 ICD9CM:011.9 ICD9CM:011.90 MESH:D014397 NCI:C26899 UMLS_CUI:C0041327

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 3 alleles in 3 genetic backgrounds
38 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

4
Gene trapped

1
Targeted

9
Transgenic

1
Incidental Mutations

APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele develop an exaggerated delayed-type hypersensitivity response and are more susceptible to experimental autoimmune encephalomyelitis due to the presence of an increased number of Th17 cells.

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All GO Annotations

25
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

722
Tissues

7
cDNA Data

5
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

34
RefSeq

6
UniProt

1
CCDS

CCDS21835.1

Ensembl

ENSMUSG00000044701 (Evidence)
NCBI Gene

246779

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044701	Ensembl Gene Model \| MGI Sequence Detail	5932	C57BL/6J	± kb
transcript	ENSMUST00000058429	Ensembl \| MGI Sequence Detail	1021	Not Applicable
polypeptide	ENSMUSP00000054637	Ensembl \| MGI Sequence Detail	234	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001385 interleukin-27 subunit alpha

(term hierarchy)
PDB

7Z0L, 7ZG0
InterPro Domains

IPR009079 Four-helical cytokine-like, core

IPR026207 Interleukin-27 alpha
GlyGen

Q8K3I6 1 site

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All nucleic 6

cDNA 5

Primer pair 1

Microarray probesets 1

Summaries

All 164

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 38
Earliest

J:77522 Pflanz S, et al., IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4(+) T Cells. Immunity. 2002 Jun;16(6):779-90
Latest

J:350746 Bradford SD, et al., IL-27 alters inflammatory cytokine expression and limits protective immunity against Mycobacterium tuberculosis in a neonatal BCG vaccination model. Front Immunol. 2024;15:1217098

TSS for Il27:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr74783	Chr7:126194184-126194209 (-)	-84 bp
Tssr74782	Chr7:126194097-126194111 (-)	9 bp
Tssr74781	Chr7:126192045-126192056 (-)	2,062 bp
Tssr74780	Chr7:126189425-126189428 (-)	4,686 bp
Tssr74779	Chr7:126189228-126189256 (-)	4,871 bp
Tssr74778	Chr7:126188992-126189017 (-)	5,108 bp
Tssr74777	Chr7:126188619-126188636 (-)	5,485 bp
Tssr74776	Chr7:126188580-126188587 (-)	5,529 bp
Tssr74775	Chr7:126188573-126188578 (-)	5,537 bp
Tssr74774	Chr7:126188471-126188476 (-)	5,639 bp
Tssr74773	Chr7:126188428-126188445 (-)	5,676 bp
Tssr74772	Chr7:126188410-126188421 (-)	5,697 bp
Tssr74771	Chr7:126188337-126188348 (-)	5,770 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24