Armc5 MGI Mouse Gene Detail - MGI:2384586 - armadillo repeat containing 5

Symbol

Armc5
Name

armadillo repeat containing 5
Synonyms

MGC:36606

Feature Type

protein coding gene
IDs

MGI:2384586
NCBI Gene: 233912
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr7:127836514-127844272 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 70.06 cM
Mapping Data

2 experiments

SNPs within 2kb

182 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384586	protein coding gene	Chr7:127836460-127844272 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033077	protein coding gene	Chr7:132643744-132651196 (+)
A/J	MGP_AJ_G0033059	protein coding gene	Chr7:129081378-129090224 (+)
AKR/J	MGP_AKRJ_G0032991	protein coding gene	Chr7:132458656-132466070 (+)
BALB/cJ	MGP_BALBcJ_G0033060	protein coding gene	Chr7:128746226-128754307 (+)
C3H/HeJ	MGP_C3HHeJ_G0032774	protein coding gene	Chr7:132342594-132350008 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033570	protein coding gene	Chr7:137819601-137829261 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030542	protein coding gene	Chr7:130264159-130271514 (+)
CAST/EiJ	MGP_CASTEiJ_G0032104	protein coding gene	Chr7:124132524-124139890 (+)
CBA/J	MGP_CBAJ_G0032747	protein coding gene	Chr7:142515665-142525281 (+)
DBA/2J	MGP_DBA2J_G0032899	protein coding gene	Chr7:127071167-127079042 (+)
FVB/NJ	MGP_FVBNJ_G0032852	protein coding gene	Chr7:126929982-126937725 (+)
LP/J	MGP_LPJ_G0032993	protein coding gene	Chr7:134124793-134132245 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032884	protein coding gene	Chr7:143553007-143562197 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033589	protein coding gene	Chr7:131420353-131428705 (+)
PWK/PhJ	MGP_PWKPhJ_G0031810	protein coding gene	Chr7:120079108-120086564 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031656	protein coding gene	Chr7:118231587-118238924 (+)
WSB/EiJ	MGP_WSBEiJ_G0032215	protein coding gene	Chr7:132398787-132407606 (+)

Human Ortholog

ARMC5, armadillo repeat containing 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARMC5, armadillo repeat containing 5
Synonyms

AIMAH2
Links

HGNC:25781

NCBI Gene ID: 79798

neXtProt AC: NX_Q96C12

UniProt: Q96C12
Chr Location

16p11.2; chr16:31458080-31467167 (+) GRCh38

MGI Vertebrate Homology

Armc5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARMC5
Gene Tree

Armc5

Diseases

1 with human ARMC5 associations

				Human Disease	Mouse Models
				ACTH-independent macronodular adrenal hyperplasia 2 IDs ACTH-independent macronodular adrenal hyperplasia 2 DOID:0111624 OMIM:615954

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Gene trapped

1
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit embryonic lethality with defects in mesoderm formation and gastrulation. The few survbiving mice are smaller than normal. Mice heterozygous for the same allele exhibit abnormal adrenocortical morphology and function.

less

All GO Annotations

20
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

1
cDNA Data

33
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase armc5

less

All Sequences

40
RefSeq

4
UniProt

2
CCDS

CCDS21892.1

Ensembl

ENSMUSG00000042178 (Evidence)
NCBI Gene

233912

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042178	Ensembl Gene Model \| MGI Sequence Detail	7759	C57BL/6J	± kb
transcript	ENSMUST00000044660	Ensembl \| MGI Sequence Detail	3834	Not Applicable
polypeptide	ENSMUSP00000040568	Ensembl \| MGI Sequence Detail	926	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000029280 armadillo repeat-containing protein 5

(term hierarchy)
InterPro Domains

IPR000225 Armadillo

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR000210 BTB/POZ domain

IPR011333 SKP1/BTB/POZ domain superfamily
GlyGen

Q5EBP3 1 site, 1 N-linked glycan (1 site)

less

All nucleic 33

cDNA 33

Microarray probesets 3

less

MGI:2142196

Summaries

All 33

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 8
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:244906 Berthon A, et al., Age-dependent effects of Armc5 haploinsufficiency on adrenocortical function. Hum Mol Genet. 2017 Sep 15;26(18):3495-3507

TSS for Armc5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69407	Chr7:127836456-127836501 (+)	-35 bp
Tssr69408	Chr7:127836502-127836559 (+)	17 bp
Tssr69409	Chr7:127836563-127836573 (+)	54 bp
Tssr69410	Chr7:127836683-127836726 (+)	191 bp
Tssr69411	Chr7:127837264-127837295 (+)	766 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24