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Ndrg4 Gene Detail
Summary
  • Symbol
    Ndrg4
  • Name
    N-myc downstream regulated gene 4
  • Synonyms
    D8Bwg1337e, MGC:7067, Ndr1-rs, Ndr4, SMAP-8
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384590
    NCBI Gene: 234593
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:96403602-96441584 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 47.12 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1059 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384590
 protein coding gene Chr8:96403602-96441747 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033991
 protein coding gene Chr8:97170287-97221168 (+)
A/J MGP_AJ_G0033974
 protein coding gene Chr8:93356439-93393990 (+)
AKR/J MGP_AKRJ_G0033900
 protein coding gene Chr8:95937863-95974947 (+)
BALB/cJ MGP_BALBcJ_G0033966
 protein coding gene Chr8:93448774-93487226 (+)
C3H/HeJ MGP_C3HHeJ_G0033676
 protein coding gene Chr8:96640623-96678899 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034487
 protein coding gene Chr8:100743328-100787212 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031428
 protein coding gene Chr8:87157715-87195061 (+)
CAST/EiJ MGP_CASTEiJ_G0033008
 protein coding gene Chr8:96227547-96267290 (+)
CBA/J MGP_CBAJ_G0033652
 protein coding gene Chr8:104029292-104077531 (+)
DBA/2J MGP_DBA2J_G0033806
 protein coding gene Chr8:92849247-92889380 (+)
FVB/NJ MGP_FVBNJ_G0033753
 protein coding gene Chr8:91811619-91850861 (+)
LP/J MGP_LPJ_G0033898
 protein coding gene Chr8:97311510-97353007 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033795
 protein coding gene Chr8:106256012-106294212 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034505
 protein coding gene Chr8:96095208-96132914 (+)
PWK/PhJ MGP_PWKPhJ_G0032710
 protein coding gene Chr8:92215125-92253842 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032547
 protein coding gene Chr8:94932704-94971830 (+)
WSB/EiJ MGP_WSBEiJ_G0033120
 protein coding gene Chr8:96604214-96649112 (+)



Homology
more
  • Human Ortholog
    NDRG4, NDRG family member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NDRG4, NDRG family member 4
  • Synonyms
    BDM1, SMAP-8, SMAP8
  • Links
    NCBI Gene ID: 65009
    neXtProt AC: NX_Q9ULP0
    UniProt: Q9ULP0

  • Chr Location
    16q21; chr16:58462846-58515387 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit spatial learning deficits and increased susceptibility to ischemic brain injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1083
  • Tissues
    161
  • cDNA Data
    126
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 234593 NCBI Gene Model | MGI Sequence Detail 37983 C57BL/6J ±  kb
    transcript NM_001372427 RefSeq | MGI Sequence Detail 3140 C57BL/6  
    polypeptide Q8BTG7 UniProt | EBI | MGI Sequence Detail 352 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 131
      cDNA 127
      Primer pair 3
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-34121, MGD-MRK-37557, MGI:106427, MGI:108513, MGI:2142896
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 11
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory