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Ttc36 Gene Detail
Summary
  • Symbol
    Ttc36
  • Name
    tetratricopeptide repeat domain 36
  • Synonyms
    MGC:25970, MGC:37247, MGC:37838
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384760
    NCBI Gene: 192653
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44710697-44714248 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384760
 protein coding gene Chr9:44710694-44714369 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034720
 protein coding gene Chr9:43328906-43332453 (-)
A/J MGP_AJ_G0034701
 protein coding gene Chr9:42110251-42113802 (-)
AKR/J MGP_AKRJ_G0034628
 protein coding gene Chr9:42984409-42987960 (-)
BALB/cJ MGP_BALBcJ_G0034692
 protein coding gene Chr9:41850605-41854156 (-)
C3H/HeJ MGP_C3HHeJ_G0034403
 protein coding gene Chr9:43434502-43438053 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035213
 protein coding gene Chr9:44607196-44610747 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032128
 protein coding gene Chr9:41671150-41674394 (-)
CAST/EiJ MGP_CASTEiJ_G0033725
 protein coding gene Chr9:43295712-43299251 (-)
CBA/J MGP_CBAJ_G0034375
 protein coding gene Chr9:46237224-46240775 (-)
DBA/2J MGP_DBA2J_G0034534
 protein coding gene Chr9:42007923-42011474 (-)
FVB/NJ MGP_FVBNJ_G0034475
 protein coding gene Chr9:41269173-41272724 (-)
LP/J MGP_LPJ_G0034615
 protein coding gene Chr9:43628899-43632446 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034519
 protein coding gene Chr9:48079804-48083355 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035234
 protein coding gene Chr9:42906571-42910122 (-)
PWK/PhJ MGP_PWKPhJ_G0033430
 protein coding gene Chr9:41893706-41897253 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033266
 protein coding gene Chr9:43202026-43205555 (-)
WSB/EiJ MGP_WSBEiJ_G0033838
 protein coding gene Chr9:42928127-42931678 (-)



Homology
more
  • Human Ortholog
    TTC36, tetratricopeptide repeat domain 36
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TTC36, tetratricopeptide repeat domain 36
  • Synonyms
    HBP21
  • Links
    NCBI Gene ID: 143941
    neXtProt AC: NX_A6NLP5
    UniProt: A6NLP5

  • Chr Location
    11q23.3; chr11:118527472-118531197 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Mice homozygous for a null allele exhibit normal reproduction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    880
  • Tissues
    83
  • cDNA Data
    90
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 192653 NCBI Gene Model | MGI Sequence Detail 3552 C57BL/6J ±  kb
transcript NM_138951 RefSeq | MGI Sequence Detail 789 FVB/N  
polypeptide Q8VBW8 UniProt | EBI | MGI Sequence Detail 186 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 92
    cDNA 90
    Primer pair 1
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Developmental Gene Expression 6
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:281174 Xie Y, et al., HPD degradation regulated by the TTC36-STK33-PELI1 signaling axis induces tyrosinemia and neurological damage. Nat Commun. 2019 Sep 19;10(1):4266
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory