Slc25a38 MGI Mouse Gene Detail - MGI:2384782 - solute carrier family 25, member 38

Symbol

Slc25a38
Name

solute carrier family 25, member 38
Synonyms

appoptosin, MGC:18873

Feature Type

protein coding gene
IDs

MGI:2384782
NCBI Gene: 208638
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr9:119939440-119953570 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 71.40 cM
Mapping Data

2 experiments

SNPs within 2kb

554 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384782	protein coding gene	Chr9:119939428-119953570 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035431	protein coding gene	Chr9:122929698-122947050 (+)
A/J	MGP_AJ_G0035412	protein coding gene	Chr9:118328185-118342218 (+)
AKR/J	MGP_AKRJ_G0035345	protein coding gene	Chr9:121428829-121442820 (+)
BALB/cJ	MGP_BALBcJ_G0035408	protein coding gene	Chr9:118223230-118238298 (+)
C3H/HeJ	MGP_C3HHeJ_G0035116	protein coding gene	Chr9:121906353-121921681 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035931	protein coding gene	Chr9:126294906-126311086 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032813	protein coding gene	Chr9:115524017-115543656 (+)
CAST/EiJ	MGP_CASTEiJ_G0034420	protein coding gene	Chr9:121910164-121927754 (+)
CBA/J	MGP_CBAJ_G0035083	protein coding gene	Chr9:131015440-131029407 (+)
DBA/2J	MGP_DBA2J_G0035242	protein coding gene	Chr9:117778186-117792194 (+)
FVB/NJ	MGP_FVBNJ_G0035189	protein coding gene	Chr9:116653785-116676724 (+)
LP/J	MGP_LPJ_G0035321	protein coding gene	Chr9:123268418-123282906 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035230	protein coding gene	Chr9:131955032-131971877 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035950	protein coding gene	Chr9:121813036-121834133 (+)
PWK/PhJ	MGP_PWKPhJ_G0034125	protein coding gene	Chr9:118218639-118232683 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033961	protein coding gene	Chr9:121923195-121938555 (+)
WSB/EiJ	MGP_WSBEiJ_G0034540	protein coding gene	Chr9:121709089-121723227 (+)

Human Ortholog

SLC25A38, solute carrier family 25 member 38

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC25A38, solute carrier family 25 member 38
Synonyms

SIDBA2
Links

HGNC:26054

NCBI Gene ID: 54977

neXtProt AC: NX_Q96DW6

UniProt: Q96DW6
Chr Location

3p22.1; chr3:39383370-39397351 (+) GRCh38

MGI Vertebrate Homology

Slc25a38 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SLC25A38
Gene Tree

Slc25a38

Diseases

1 with human SLC25A38 associations

				Human Disease	Mouse Models
				autosomal recessive pyridoxine-refractory sideroblastic anemia 2 IDs autosomal recessive pyridoxine-refractory sideroblastic anemia 2 DOID:0060065 OMIM:205950

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

2
Gene trapped

11
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

770
Tissues

8
cDNA Data

54
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc25a38

ZFIN slc25a38a, slc25a38b

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All Sequences

61
RefSeq

18
UniProt

4
CCDS

CCDS23622.1

Ensembl

ENSMUSG00000032519 (Evidence)
NCBI Gene

208638

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032519	Ensembl Gene Model \| MGI Sequence Detail	14131	C57BL/6J	± kb
transcript	ENSMUST00000035106	Ensembl \| MGI Sequence Detail	1791	Not Applicable
polypeptide	ENSMUSP00000035106	Ensembl \| MGI Sequence Detail	326	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000030786 mitochondrial glycine transporter

(term hierarchy)
InterPro Domains

IPR023395 Mitochondrial carrier domain superfamily

IPR030847 Mitochondrial glycine transporter Hem25/SLC25A38

IPR018108 Mitochondrial substrate/solute carrier

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All nucleic 55

cDNA 54

Primer pair 1

Microarray probesets 3

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MGI:2143250

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 12
Earliest

J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc25a38:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87708	Chr9:119939415-119939484 (+)	10 bp
Tssr87709	Chr9:119939563-119939574 (+)	129 bp
Tssr87710	Chr9:119943963-119944022 (+)	4,553 bp
Tssr87711	Chr9:119944028-119944044 (+)	4,596 bp
Tssr87712	Chr9:119944059-119944074 (+)	4,627 bp
Tssr87713	Chr9:119945303-119945312 (+)	5,868 bp
Tssr87714	Chr9:119945573-119945592 (+)	6,143 bp
Tssr3053	Chr9:119949773-119949780 (+)	10,337 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24