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Enox2 Gene Detail
Summary
  • Symbol
    Enox2
  • Name
    ecto-NOX disulfide-thiol exchanger 2
  • Synonyms
    APK1, Cova1, MGC:32453, tNOX
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384799
    NCBI Gene: 209224
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:48098584-48377126 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 25.79 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5686 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384799
 protein coding gene ChrX:48098584-48377136 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035700
 protein coding gene ChrX:44187879-44469273 (-)
A/J MGP_AJ_G0035683
 protein coding gene ChrX:44024517-44308483 (-)
AKR/J MGP_AKRJ_G0035603
 protein coding gene ChrX:45257509-45543180 (-)
BALB/cJ MGP_BALBcJ_G0035669
 protein coding gene ChrX:43655741-43933104 (-)
C3H/HeJ MGP_C3HHeJ_G0035373
 protein coding gene ChrX:44458908-44743645 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036198
 protein coding gene ChrX:45199217-45487907 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033050
 protein coding gene ChrX:41695210-41977347 (-)
CAST/EiJ MGP_CASTEiJ_G0034664
 protein coding gene ChrX:32017738-32310014 (-)
CBA/J MGP_CBAJ_G0035347
 protein coding gene ChrX:46505609-46805077 (-)
DBA/2J MGP_DBA2J_G0035501
 protein coding gene ChrX:43856402-44147795 (-)
FVB/NJ MGP_FVBNJ_G0035450
 protein coding gene ChrX:43586617-43873945 (-)
LP/J MGP_LPJ_G0035589
 protein coding gene ChrX:44551384-44837421 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035488
 protein coding gene ChrX:47914896-48244889 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036216
 protein coding gene ChrX:44076744-44366736 (-)
PWK/PhJ MGP_PWKPhJ_G0034363
 protein coding gene ChrX:31490831-31771027 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034208
 protein coding gene ChrX:32851687-33122371 (-)
WSB/EiJ MGP_WSBEiJ_G0034808
 protein coding gene ChrX:43695888-43980575 (-)



Homology
more
  • Human Ortholog
    ENOX2, ecto-NOX disulfide-thiol exchanger 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ENOX2, ecto-NOX disulfide-thiol exchanger 2
  • Synonyms
    APK1, COVA1, tNOX
  • Links
    NCBI Gene ID: 10495
    neXtProt AC: NX_Q16206
    UniProt: Q16206

  • Chr Location
    Xq26.1; chrX:130622325-130903234 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 images
    9 phenotype references
Male chimeras hemizygous for a gene trapped allele appear normal at E9.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    751
  • Tissues
    27
  • cDNA Data
    25
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 209224 NCBI Gene Model | MGI Sequence Detail 278543 C57BL/6J ±  kb
transcript NM_001271447 RefSeq | MGI Sequence Detail 3977 C57BL/6  
polypeptide Q8R0Z2 UniProt | EBI | MGI Sequence Detail 598 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    cDNA 26
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2147861
References
more
  • Summaries
    All 41
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory