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Wfdc5 Gene Detail
Summary
  • Symbol
    Wfdc5
  • Name
    WAP four-disulfide core domain 5
  • Synonyms
    PRG5, WAP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384800
    NCBI Gene: 209232
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164018247-164024662 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 84.60 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    341 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384800
 protein coding gene Chr2:164018245-164024662 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026838
 protein coding gene Chr2:169569940-169577743 (-)
A/J MGP_AJ_G0026804
 protein coding gene Chr2:162700313-162706724 (-)
AKR/J MGP_AKRJ_G0026775
 protein coding gene Chr2:167523174-167529593 (-)
BALB/cJ MGP_BALBcJ_G0026813
 protein coding gene Chr2:163042984-163049471 (-)
C3H/HeJ MGP_C3HHeJ_G0026555
 protein coding gene Chr2:167877285-167883708 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027261
 protein coding gene Chr2:174502694-174509200 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024631
 protein coding gene Chr2:156011929-156018414 (-)
CAST/EiJ MGP_CASTEiJ_G0026016
 protein coding gene Chr2:168300053-168309085 (-)
CBA/J MGP_CBAJ_G0026532
 protein coding gene Chr2:180788468-180794941 (-)
DBA/2J MGP_DBA2J_G0026670
 protein coding gene Chr2:161870091-161876510 (-)
FVB/NJ MGP_FVBNJ_G0026636
 protein coding gene Chr2:160248291-160254708 (-)
LP/J MGP_LPJ_G0026773
 protein coding gene Chr2:169669146-169677464 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026658
 protein coding gene Chr2:184451628-184458076 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027317
 protein coding gene Chr2:167423520-167429947 (-)
PWK/PhJ MGP_PWKPhJ_G0025750
 protein coding gene Chr2:161448597-161455061 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025553
 protein coding gene Chr2:166297687-166305839 (-)
WSB/EiJ MGP_WSBEiJ_G0026086
 protein coding gene Chr2:168288859-168295273 (-)



Homology
more
  • Human Ortholog
    WFDC5, WAP four-disulfide core domain 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WFDC5, WAP four-disulfide core domain 5
  • Synonyms
    dJ211D12.5, PRG5, WAP1
  • Links
    NCBI Gene ID: 149708
    neXtProt AC: NX_Q8TCV5
    UniProt: Q8TCV5

  • Chr Location
    20q13.12; chr20:45109452-45116319 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040154 Ensembl Gene Model | MGI Sequence Detail 6416 C57BL/6J ±  kb
transcript ENSMUST00000045127 Ensembl | MGI Sequence Detail 2322 Not Applicable  
polypeptide ENSMUSP00000035824 Ensembl | MGI Sequence Detail 126 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR036645 Elafin-like superfamily
    IPR050514 WAP four-disulfide core domain
    IPR008197 WAP-type 'four-disulfide core' domain
Molecular
Reagents
less
  • All nucleic 5
    Genomic 1
    cDNA 4

    Microarray probesets 2
References
more
  • Summaries
    All 23
    Gene Ontology 1
    Phenotypes 6
  • Earliest
    J:99265 Clauss A, et al., The evolution of a genetic locus encoding small serine proteinase inhibitors. Biochem Biophys Res Commun. 2005 Jul 29;333(2):383-9
  • Latest
    J:300068 Andrade AD, et al., Lipopolysaccharide-induced epididymitis modifies the transcriptional profile of Wfdc genes in mice. Biol Reprod. 2021 Jan 4;104(1):144-158
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory