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Gps1 Gene Detail
Summary
  • Symbol
    Gps1
  • Name
    G protein pathway suppressor 1
  • Synonyms
    COPS1, Csn1, MGC:7191
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384801
    NCBI Gene: 209318
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:120675098-120679928 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 84.54 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    120 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384801
 protein coding gene Chr11:120675086-120679928 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019529
 protein coding gene Chr11:125277440-125288121 (+)
A/J MGP_AJ_G0019496
 protein coding gene Chr11:119696255-119701089 (+)
AKR/J MGP_AKRJ_G0019466
 protein coding gene Chr11:123315783-123320443 (+)
BALB/cJ MGP_BALBcJ_G0019471
 protein coding gene Chr11:120052122-120058090 (+)
C3H/HeJ MGP_C3HHeJ_G0019277
 protein coding gene Chr11:123643706-123650287 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019920
 protein coding gene Chr11:129068942-129092851 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017545
 protein coding gene Chr11:116684763-116689569 (+)
CAST/EiJ MGP_CASTEiJ_G0018831
 protein coding gene Chr11:125146131-125150975 (+)
CBA/J MGP_CBAJ_G0019248
 protein coding gene Chr11:134101083-134105954 (+)
DBA/2J MGP_DBA2J_G0019361
 protein coding gene Chr11:119065506-119074200 (+)
FVB/NJ MGP_FVBNJ_G0019352
 protein coding gene Chr11:118779873-118787925 (+)
LP/J MGP_LPJ_G0019432
 protein coding gene Chr11:125571943-125581329 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019385
 protein coding gene Chr11:132930987-132938483 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019959
 protein coding gene Chr11:123981757-123989758 (+)
PWK/PhJ MGP_PWKPhJ_G0018597
 protein coding gene Chr11:120504363-120509367 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018389
 protein coding gene Chr11:123749811-123754631 (+)
WSB/EiJ MGP_WSBEiJ_G0018884
 protein coding gene Chr11:123976081-123981000 (+)



Homology
more
  • Human Ortholog
    GPS1, G protein pathway suppressor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPS1, G protein pathway suppressor 1
  • Synonyms
    COPS1, CSN1, SGN1
  • Links
    NCBI Gene ID: 2873
    neXtProt AC: NX_Q13098
    UniProt: Q13098

  • Chr Location
    17q25.3; chr17:82050691-82057470 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    742
  • Tissues
    27
  • cDNA Data
    6
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025156 Ensembl Gene Model | MGI Sequence Detail 4831 C57BL/6J ±  kb
transcript ENSMUST00000172809 Ensembl | MGI Sequence Detail 2000 Not Applicable  
polypeptide ENSMUSP00000133855 Ensembl | MGI Sequence Detail 526 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000008202 COP9 signalosome complex subunit 1
    (term hierarchy)
  • InterPro Domains
    IPR019585 26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1
    IPR045135 26S proteasome regulatory subunit Rpn7, N-terminal
    IPR048624 COP9 signalosome complex subunit 1, C-terminal helix
    IPR000717 Proteasome component (PCI) domain
    IPR036390 Winged helix DNA-binding domain superfamily
  • GlyGen
    Q99LD4 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 4
Other
Accession IDs
less
MGI:2144715
References
more
  • Summaries
    All 34
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:50270 Wei N, et al., The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Curr Biol. 1998 Jul 30-Aug 13;8(16):919-22
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory