Metrnl MGI Mouse Gene Detail - MGI:2384806 - meteorin, glial cell differentiation regulator-like

Symbol

Metrnl
Name

meteorin, glial cell differentiation regulator-like
Synonyms

9430048M07Rik

Feature Type

protein coding gene
IDs

MGI:2384806
NCBI Gene: 210029
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr11:121592370-121607132 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 86.89 cM
Mapping Data

1 experiment

SNPs within 2kb

332 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384806	protein coding gene	Chr11:121592370-121608215 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019553	protein coding gene	Chr11:126255619-126269132 (+)
A/J	MGP_AJ_G0019520	protein coding gene	Chr11:120608006-120621522 (+)
AKR/J	MGP_AKRJ_G0019490	protein coding gene	Chr11:124275668-124289171 (+)
BALB/cJ	MGP_BALBcJ_G0019495	protein coding gene	Chr11:120989681-121003199 (+)
C3H/HeJ	MGP_C3HHeJ_G0019301	protein coding gene	Chr11:124603594-124617104 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019944	protein coding gene	Chr11:130081781-130095295 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017569	protein coding gene	Chr11:117600386-117614161 (+)
CAST/EiJ	MGP_CASTEiJ_G0018855	protein coding gene	Chr11:126086758-126129952 (+)
CBA/J	MGP_CBAJ_G0019272	protein coding gene	Chr11:135130721-135144153 (+)
DBA/2J	MGP_DBA2J_G0019385	protein coding gene	Chr11:119999885-120013370 (+)
FVB/NJ	MGP_FVBNJ_G0019376	protein coding gene	Chr11:119724386-119737883 (+)
LP/J	MGP_LPJ_G0019456	protein coding gene	Chr11:126538607-126552125 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019409	protein coding gene	Chr11:133929630-133943103 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019983	protein coding gene	Chr11:124964928-124978440 (+)
PWK/PhJ	MGP_PWKPhJ_G0018622	protein coding gene	Chr11:121432987-121470312 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018413	protein coding gene	Chr11:124699539-124713383 (+)
WSB/EiJ	MGP_WSBEiJ_G0018908	protein coding gene	Chr11:124923094-124941484 (+)

Human Ortholog

METRNL, meteorin like, glial cell differentiation regulator

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

METRNL, meteorin like, glial cell differentiation regulator
Links

HGNC:27584

NCBI Gene ID: 284207

neXtProt AC: NX_Q641Q3

UniProt: Q641Q3
Chr Location

17q25.3; chr17:83079609-83095122 (+) GRCh38

MGI Vertebrate Homology

Metrnl stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: METRNL
Gene Tree

Metrnl

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

4
Targeted

10
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased LPS-induced mortality, altered Ig serum levels and inflammation in the uterus, kidney and liver.

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All GO Annotations

15
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

854
Tissues

50
cDNA Data

47
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase metrnl

ZFIN metrnla

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All Sequences

43
RefSeq

2
UniProt

3
CCDS

CCDS25781.1

Ensembl

ENSMUSG00000039208 (Evidence)
NCBI Gene

210029

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039208	Ensembl Gene Model \| MGI Sequence Detail	14763	C57BL/6J	± kb
transcript	ENSMUST00000036742	Ensembl \| MGI Sequence Detail	1401	Not Applicable
polypeptide	ENSMUSP00000038126	Ensembl \| MGI Sequence Detail	311	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010339 meteorin-like protein

(term hierarchy)
PDB

7TLW
InterPro Domains

IPR051998 Meteorin-like
GlyGen

Q8VE43 1 site

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All nucleic 49

cDNA 48

Primer pair 1

Microarray probesets 4

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MGI:2444092

Summaries

All 46

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 17
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:353386 Jackson CM, et al., The cytokine Meteorin-like inhibits anti-tumor CD8(+) T cell responses by disrupting mitochondrial function. Immunity. 2024 Aug 13;57(8):1864-1877.e9

TSS for Metrnl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106417	Chr11:121593219-121593230 (+)	855 bp
Tssr106418	Chr11:121593244-121593260 (+)	882 bp
Tssr106419	Chr11:121593279-121593293 (+)	916 bp
Tssr106420	Chr11:121593354-121593365 (+)	990 bp
Tssr106421	Chr11:121593401-121593412 (+)	1,037 bp
Tssr106422	Chr11:121593417-121593442 (+)	1,060 bp
Tssr106423	Chr11:121593582-121593592 (+)	1,217 bp
Tssr106424	Chr11:121597420-121597430 (+)	5,055 bp
Tssr106425	Chr11:121599506-121599508 (+)	7,137 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24