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Lpcat1 Gene Detail
Summary
  • Symbol
    Lpcat1
  • Name
    lysophosphatidylcholine acyltransferase 1
  • Synonyms
    2900035H07Rik, Aytl2, LPCAT, MGC:8148, rd11
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384812
    NCBI Gene: 210992
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:73615332-73664539 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 39.97 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1335 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384812
 protein coding gene Chr13:73615316-73664541 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020745
 protein coding gene Chr13:73916129-73965321 (+)
A/J MGP_AJ_G0020701
 protein coding gene Chr13:71287960-71337607 (+)
AKR/J MGP_AKRJ_G0020675
 protein coding gene Chr13:73528528-73578822 (+)
BALB/cJ MGP_BALBcJ_G0020698
 protein coding gene Chr13:71779071-71828209 (+)
C3H/HeJ MGP_C3HHeJ_G0020492
 protein coding gene Chr13:73209602-73259776 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021135
 protein coding gene Chr13:76391099-76441574 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018702
 protein coding gene Chr13:68103070-68157368 (+)
CAST/EiJ MGP_CASTEiJ_G0020009
 protein coding gene Chr13:72284683-72338085 (+)
CBA/J MGP_CBAJ_G0020451
 protein coding gene Chr13:79230930-79282449 (+)
DBA/2J MGP_DBA2J_G0020576
 protein coding gene Chr13:71107436-71156859 (+)
FVB/NJ MGP_FVBNJ_G0020556
 protein coding gene Chr13:70130122-70179321 (+)
LP/J MGP_LPJ_G0020649
 protein coding gene Chr13:74163507-74213364 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020584
 protein coding gene Chr13:77668578-77718816 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021174
 protein coding gene Chr13:72834863-72885318 (+)
PWK/PhJ MGP_PWKPhJ_G0019763
 protein coding gene Chr13:69840570-69892003 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019586
 protein coding gene Chr13:69298818-69349357 (+)
WSB/EiJ MGP_WSBEiJ_G0020067
 protein coding gene Chr13:73382192-73432831 (+)



Homology
more
  • Human Ortholog
    LPCAT1, lysophosphatidylcholine acyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LPCAT1, lysophosphatidylcholine acyltransferase 1
  • Synonyms
    AGPAT10, AGPAT9, AYTL2, lpcat, LPCAT-1, LPLAT8, lysoPAFAT, PFAAP3
  • Links
    NCBI Gene ID: 79888
    neXtProt AC: NX_Q8NF37
    UniProt: Q8NF37

  • Chr Location
    5p15.33; chr5:1456480-1523962 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 4 alleles in 4 genetic backgrounds
    2 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Some mice homozygous for a gene trapped allele exhibit neonatal lethality associated with respiratory distress, cyanosis, atelectasis, lung hemorrhage, and defective surfactant function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    806
  • Tissues
    54
  • cDNA Data
    18
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 210992 NCBI Gene Model | MGI Sequence Detail 49208 C57BL/6J ±  kb
    transcript NM_145376 RefSeq | MGI Sequence Detail 3632 C57BL/6  
    polypeptide Q3TFD2 UniProt | EBI | MGI Sequence Detail 534 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 19
      Primer pair 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1923850, MGI:2142294, MGI:2145536, MGI:2157071
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 13
      Gene Ontology 12
      Phenotypes 26
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:354192 He H, et al., PRDM3/16 regulate chromatin accessibility required for NKX2-1 mediated alveolar epithelial differentiation and function. Nat Commun. 2024 Sep 16;15(1):8112
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory