Vstm2a MGI Mouse Gene Detail - MGI:2384826 - V-set and transmembrane domain containing 2A

Symbol

Vstm2a
Name

V-set and transmembrane domain containing 2A
Synonyms

9330184N17Rik, MGC:38877, Vstm2

Feature Type

protein coding gene
IDs

MGI:2384826
NCBI Gene: 211739
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:16207742-16234551 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 8.89 cM
Mapping Data

1 experiment

SNPs within 2kb

803 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384826	protein coding gene	Chr11:16207724-16377310 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018050	protein coding gene	Chr11:13632306-13805143 (+)
A/J	MGP_AJ_G0018023	protein coding gene	Chr11:13165700-13334634 (+)
AKR/J	MGP_AKRJ_G0017987	protein coding gene	Chr11:13643496-13812140 (+)
BALB/cJ	MGP_BALBcJ_G0017991	protein coding gene	Chr11:13274960-13436241 (+)
C3H/HeJ	MGP_C3HHeJ_G0017804	protein coding gene	Chr11:13553160-13733156 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018443	protein coding gene	Chr11:14184296-14376060 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016101	protein coding gene	Chr11:12383516-12540827 (+)
CAST/EiJ	MGP_CASTEiJ_G0017366	protein coding gene	Chr11:13558331-13721692 (+)
CBA/J	MGP_CBAJ_G0017779	protein coding gene	Chr11:15000319-15201691 (+)
DBA/2J	MGP_DBA2J_G0017889	protein coding gene	Chr11:13141822-13318534 (+)
FVB/NJ	MGP_FVBNJ_G0017881	protein coding gene	Chr11:12950171-13122835 (+)
LP/J	MGP_LPJ_G0017960	protein coding gene	Chr11:13795835-13959718 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017907	protein coding gene	Chr11:15445412-15626734 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018484	protein coding gene	Chr11:13716489-13878429 (+)
PWK/PhJ	MGP_PWKPhJ_G0017146	protein coding gene	Chr11:13141270-13300535 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016943	protein coding gene	Chr11:13506189-13660596 (+)
WSB/EiJ	MGP_WSBEiJ_G0017420	protein coding gene	Chr11:13399504-13580969 (+)

Human Ortholog

VSTM2A, V-set and transmembrane domain containing 2A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VSTM2A, V-set and transmembrane domain containing 2A
Synonyms

VSTM2
Links

HGNC:28499

NCBI Gene ID: 222008

neXtProt AC: NX_Q8TAG5

UniProt: Q8TAG5
Chr Location

7p11.2; chr7:54542325-54571080 (+) GRCh38

MGI Vertebrate Homology

Vstm2a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: VSTM2A
Gene Tree

Vstm2a

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

842
Tissues

16
cDNA Data

15
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

53
RefSeq

8
UniProt

4
CCDS

CCDS24441.2

Ensembl

ENSMUSG00000048834 (Evidence)
NCBI Gene

211739

			Length	Strain/Species	Flank
genomic	211739	NCBI Gene Model \| MGI Sequence Detail	26810	C57BL/6J	± kb
transcript	NM_001363461	RefSeq \| MGI Sequence Detail	3749	C57BL/6
polypeptide	Q8R0A6	UniProt \| EBI \| MGI Sequence Detail	236	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000032181 V-set and transmembrane domain-containing protein 2A

(term hierarchy)
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR051102 Immunoglobulin superfamily V-set and transmembrane domain-containing protein

IPR013106 Immunoglobulin V-set domain
GlyGen

Q8R0A6 2 sites, 2 N-linked glycans (1 site)

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All nucleic 16

cDNA 15

Other 1

Microarray probesets 5

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MGI:2444299

Summaries

All 36

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 8
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Vstm2a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100401	Chr11:16207634-16207649 (+)	-100 bp
Tssr100402	Chr11:16207659-16207672 (+)	-76 bp
Tssr100403	Chr11:16207706-16207808 (+)	15 bp
Tssr100404	Chr11:16207867-16207878 (+)	131 bp
Tssr100405	Chr11:16210585-16210607 (+)	2,854 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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