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Prpsap2 Gene Detail
Summary
  • Symbol
    Prpsap2
  • Name
    phosphoribosyl pyrophosphate synthetase-associated protein 2
  • Synonyms
    A230054F23Rik, MGC:36957
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384838
    NCBI Gene: 212627
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:61620476-61652914 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 37.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    802 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384838
 protein coding gene Chr11:61620476-61652924 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018446
 protein coding gene Chr11:61702163-61738956 (-)
A/J MGP_AJ_G0018415
 protein coding gene Chr11:59431371-59467004 (-)
AKR/J MGP_AKRJ_G0018385
 protein coding gene Chr11:61270453-61303760 (-)
BALB/cJ MGP_BALBcJ_G0018386
 protein coding gene Chr11:59732124-59765805 (-)
C3H/HeJ MGP_C3HHeJ_G0018199
 protein coding gene Chr11:61257492-61292853 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018838
 protein coding gene Chr11:63664948-63699166 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016484
 protein coding gene Chr11:56544799-56578874 (-)
CAST/EiJ MGP_CASTEiJ_G0017756
 protein coding gene Chr11:61361842-61393971 (-)
CBA/J MGP_CBAJ_G0018173
 protein coding gene Chr11:66426358-66465223 (-)
DBA/2J MGP_DBA2J_G0018282
 protein coding gene Chr11:58998174-59031206 (-)
FVB/NJ MGP_FVBNJ_G0018273
 protein coding gene Chr11:58683716-58716085 (-)
LP/J MGP_LPJ_G0018355
 protein coding gene Chr11:62274803-62311281 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018297
 protein coding gene Chr11:67415982-67451570 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018879
 protein coding gene Chr11:61408629-61441964 (-)
PWK/PhJ MGP_PWKPhJ_G0017529
 protein coding gene Chr11:59604652-59638032 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017319
 protein coding gene Chr11:61235246-61273509 (-)
WSB/EiJ MGP_WSBEiJ_G0017808
 protein coding gene Chr11:61016410-61051884 (-)



Homology
more
  • Human Ortholog
    PRPSAP2, phosphoribosyl pyrophosphate synthetase associated protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRPSAP2, phosphoribosyl pyrophosphate synthetase associated protein 2
  • Synonyms
    PAP41
  • Links
    NCBI Gene ID: 5636
    neXtProt AC: NX_O60256
    UniProt: O60256

  • Chr Location
    17p11.2; chr17:18840085-18931287 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    799
  • Tissues
    39
  • cDNA Data
    65
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020528 Ensembl Gene Model | MGI Sequence Detail 32439 C57BL/6J ±  kb
    transcript ENSMUST00000168115 Ensembl | MGI Sequence Detail 1771 Not Applicable  
    polypeptide ENSMUSP00000126274 Ensembl | MGI Sequence Detail 369 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000013295 phosphoribosyl pyrophosphate synthase-associated protein 2
      (term hierarchy)
    • InterPro Domains
      IPR000836 Phosphoribosyltransferase domain
      IPR029057 Phosphoribosyltransferase-like
      IPR005946 Ribose-phosphate pyrophosphokinase
      IPR029099 Ribose-phosphate pyrophosphokinase, N-terminal domain
    Molecular
    Reagents
    less
    • All nucleic 66
      cDNA 66

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2443765
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory