About   Help   FAQ
Slc39a14 Gene Detail
Summary
  • Symbol
    Slc39a14
  • Name
    solute carrier family 39 (zinc transporter), member 14
  • Synonyms
    G630015O18Rik, MGC:38539, Zip14
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384851
    NCBI Gene: 213053
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:70540918-70588874 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 36.32 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1172 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384851
 protein coding gene Chr14:70540916-70588874 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021535
 protein coding gene Chr14:64948411-64998662 (-)
A/J MGP_AJ_G0021494
 protein coding gene Chr14:63569553-63618039 (-)
AKR/J MGP_AKRJ_G0021470
 protein coding gene Chr14:65474480-65525473 (-)
BALB/cJ MGP_BALBcJ_G0021500
 protein coding gene Chr14:63333515-63381352 (-)
C3H/HeJ MGP_C3HHeJ_G0021277
 protein coding gene Chr14:65192101-65240762 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021939
 protein coding gene Chr14:67851817-67905145 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019479
 protein coding gene Chr14:61406472-61454751 (-)
CAST/EiJ MGP_CASTEiJ_G0020794
 protein coding gene Chr14:61781333-61834837 (-)
CBA/J MGP_CBAJ_G0021244
 protein coding gene Chr14:69982620-70035075 (-)
DBA/2J MGP_DBA2J_G0021367
 protein coding gene Chr14:62951468-63000286 (-)
FVB/NJ MGP_FVBNJ_G0021346
 protein coding gene Chr14:62378833-62430630 (-)
LP/J MGP_LPJ_G0021438
 protein coding gene Chr14:66190434-66239685 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021375
 protein coding gene Chr14:68886138-68938953 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021963
 protein coding gene Chr14:64737877-64787571 (-)
PWK/PhJ MGP_PWKPhJ_G0020538
 protein coding gene Chr14:59716829-59766581 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020371
 protein coding gene Chr14:60668029-60716708 (-)
WSB/EiJ MGP_WSBEiJ_G0020847
 protein coding gene Chr14:65050418-65098176 (-)



Homology
more
  • Human Ortholog
    SLC39A14, solute carrier family 39 member 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC39A14, solute carrier family 39 member 14
  • Synonyms
    cig19, HCIN, HMNDYT2, LZT-Hs4, NET34, ZIP14
  • Links
    NCBI Gene ID: 23516
    neXtProt AC: NX_Q15043
    UniProt: Q15043

  • Chr Location
    8p21.3; chr8:22367278-22434129 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SLC39A14 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 4 alleles in 6 genetic backgrounds
    3 images
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show dwarfism, scoliosis, osteopenia, short long bones, altered gluconeogenesis and chondrocyte differentiation, low plasma IGF-I and liver zinc levels. Homozygotes for another null allele show reduced liver zinc levels and hepatocyte proliferation after hepatectomy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    949
  • Tissues
    117
  • cDNA Data
    60
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022094 Ensembl Gene Model | MGI Sequence Detail 47957 C57BL/6J ±  kb
    transcript ENSMUST00000068044 Ensembl | MGI Sequence Detail 4926 Not Applicable  
    polypeptide ENSMUSP00000066108 Ensembl | MGI Sequence Detail 489 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 63
      cDNA 62
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2443120
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 6
      Gene Ontology 13
      Phenotypes 46
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory