Scgn MGI Mouse Gene Detail - MGI:2384873 - secretagogin, EF-hand calcium binding protein

Symbol

Scgn
Name

secretagogin, EF-hand calcium binding protein
Synonyms

MGC:27615

Feature Type

protein coding gene
IDs

MGI:2384873
NCBI Gene: 214189
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr13:24137439-24175197 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 10.01 cM
Mapping Data

1 experiment

SNPs within 2kb

1365 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384873	protein coding gene	Chr13:24137439-24175310 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020375	protein coding gene	Chr13:21404122-21443917 (-)
A/J	MGP_AJ_G0020324	protein coding gene	Chr13:21009842-21048232 (-)
AKR/J	MGP_AKRJ_G0020304	protein coding gene	Chr13:21268733-21306448 (-)
BALB/cJ	MGP_BALBcJ_G0020322	protein coding gene	Chr13:21004783-21042425 (-)
C3H/HeJ	MGP_C3HHeJ_G0020126	protein coding gene	Chr13:21341077-21379358 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020759	protein coding gene	Chr13:22186752-22224425 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018347	protein coding gene	Chr13:19785369-19824500 (-)
CAST/EiJ	MGP_CASTEiJ_G0019643	protein coding gene	Chr13:21024135-21065448 (-)
CBA/J	MGP_CBAJ_G0020080	protein coding gene	Chr13:23042674-23082600 (-)
DBA/2J	MGP_DBA2J_G0020206	protein coding gene	Chr13:20539590-20577296 (-)
FVB/NJ	MGP_FVBNJ_G0020190	protein coding gene	Chr13:20186355-20224053 (-)
LP/J	MGP_LPJ_G0020279	protein coding gene	Chr13:21712100-21751128 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020217	protein coding gene	Chr13:23342646-23384919 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020801	protein coding gene	Chr13:21114251-21151907 (-)
PWK/PhJ	MGP_PWKPhJ_G0019397	protein coding gene	Chr13:20575008-20615261 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019212	protein coding gene	Chr13:19929658-19971747 (-)
WSB/EiJ	MGP_WSBEiJ_G0019703	protein coding gene	Chr13:21259702-21298274 (-)

Human Ortholog

SCGN, secretagogin, EF-hand calcium binding protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SCGN, secretagogin, EF-hand calcium binding protein
Synonyms

CALBL, DJ501N12.8, SECRET, SEGN, setagin
Links

HGNC:16941

NCBI Gene ID: 10590

neXtProt AC: NX_O76038

UniProt: O76038
Chr Location

6p22.2; chr6:25652201-25701783 (+) GRCh38

MGI Vertebrate Homology

Scgn stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SCGN
Gene Tree

Scgn

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

6
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Scgn
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous knockout increases susceptibility to DSS-induced colitis.

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All GO Annotations

9
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

904
Tissues

65
cDNA Data

10
Literature Summary

13

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase scgn

ZFIN scgn

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All Sequences

34
RefSeq

4
UniProt

2
CCDS

CCDS26375.1

Ensembl

ENSMUSG00000021337 (Evidence)
NCBI Gene

214189

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021337	Ensembl Gene Model \| MGI Sequence Detail	37759	C57BL/6J	± kb
transcript	ENSMUST00000021770	Ensembl \| MGI Sequence Detail	1412	Not Applicable
polypeptide	ENSMUSP00000021770	Ensembl \| MGI Sequence Detail	276	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014513 secretagogin

(term hierarchy)
PDB

8BAN, 8BBJ
InterPro Domains

IPR051001 Calbindin Calcium-Binding

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR035798 Secretagogin, EF-hand domain
GlyGen

Q91WD9 1 site, 1 N-linked glycan (1 site)

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All nucleic 12

cDNA 10

Primer pair 2

Microarray probesets 3

Summaries

All 62

Developmental Gene Expression 13

Gene Ontology 3

Phenotypes 20
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:338430 Wang QW, et al., 16p11.2 CNV gene Doc2alpha functions in neurodevelopment and social behaviors through interaction with Secretagogin. Cell Rep. 2023 Jun 22;42(7):112691

TSS for Scgn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121763	Chr13:24175141-24175164 (-)	44 bp
Tssr121762	Chr13:24151138-24151162 (-)	24,047 bp
Tssr121761	Chr13:24151121-24151128 (-)	24,072 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24