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Cdc73 Gene Detail
Summary
  • Symbol
    Cdc73
  • Name
    cell division cycle 73, Paf1/RNA polymerase II complex component
  • Synonyms
    8430414L16Rik, C130030P16Rik, Hrpt2, MGC:29274, MGC:36559
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384876
    NCBI Gene: 214498
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:143479014-143578631 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 62.52 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1723 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384876
 protein coding gene Chr1:143474538-143578631 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016560
 protein coding gene Chr1:147941556-148057804 (-)
A/J MGP_AJ_G0016543
 protein coding gene Chr1:142039656-142148534 (-)
AKR/J MGP_AKRJ_G0016508
 protein coding gene Chr1:146395421-146509433 (-)
BALB/cJ MGP_BALBcJ_G0016503
 protein coding gene Chr1:142462590-142567567 (-)
C3H/HeJ MGP_C3HHeJ_G0016328
 protein coding gene Chr1:146516243-146624284 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016964
 protein coding gene Chr1:152937639-153049113 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014673
 protein coding gene Chr1:134861495-134968447 (-)
CAST/EiJ MGP_CASTEiJ_G0015907
 protein coding gene Chr1:145937409-146056037 (-)
CBA/J MGP_CBAJ_G0016302
 protein coding gene Chr1:158362972-158492463 (-)
DBA/2J MGP_DBA2J_G0016408
 protein coding gene Chr1:141144517-141252795 (-)
FVB/NJ MGP_FVBNJ_G0016406
 protein coding gene Chr1:139642102-139745615 (-)
LP/J MGP_LPJ_G0016479
 protein coding gene Chr1:148963191-149076207 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016432
 protein coding gene Chr1:164801286-164926356 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017000
 protein coding gene Chr1:146131716-146244441 (-)
PWK/PhJ MGP_PWKPhJ_G0015693
 protein coding gene Chr1:140051374-140161350 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015480
 protein coding gene Chr1:144933394-145041325 (-)
WSB/EiJ MGP_WSBEiJ_G0015970
 protein coding gene Chr1:146166895-146281283 (-)



Homology
more
  • Human Ortholog
    CDC73, cell division cycle 73
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDC73, cell division cycle 73
  • Synonyms
    C1orf28, FIHP, HPTJT, HRPT1, HRPT2, HYX
  • Links
    NCBI Gene ID: 79577
    neXtProt AC: NX_Q6P1J9
    UniProt: Q6P1J9

  • Chr Location
    1q31.2; chr1:193121983-193254815 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cdc73 mouse models; 2 with human CDC73 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 3 alleles in 5 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality around hatching or implantation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    825
  • Tissues
    63
  • cDNA Data
    13
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 214498 NCBI Gene Model | MGI Sequence Detail 99618 C57BL/6J ±  kb
    transcript NM_145991 RefSeq | MGI Sequence Detail 7110 ZRU/MplStud  
    polypeptide Q8JZM7 UniProt | EBI | MGI Sequence Detail 531 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1922999, MGI:2138700, MGI:2444564
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 11
      Phenotypes 16
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:289607 Saha N, et al., The PAF1c Subunit CDC73 Is Required for Mouse Hematopoietic Stem Cell Maintenance but Displays Leukemia-Specific Gene Regulation. Stem Cell Reports. 2019 May 14;12(5):1069-1083
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory