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Hkdc1 Gene Detail
Summary
  • Symbol
    Hkdc1
  • Name
    hexokinase domain containing 1
  • Synonyms
    MGC:28816
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384910
    NCBI Gene: 216019
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:62218916-62258270 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 32.40 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1197 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384910
 protein coding gene Chr10:62218916-62259490 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017296
 protein coding gene Chr10:61810246-61851458 (-)
A/J MGP_AJ_G0017274
 protein coding gene Chr10:59919527-59958123 (-)
AKR/J MGP_AKRJ_G0017234
 protein coding gene Chr10:61481266-61521458 (-)
BALB/cJ MGP_BALBcJ_G0017234
 protein coding gene Chr10:59998634-60040145 (-)
C3H/HeJ MGP_C3HHeJ_G0017057
 protein coding gene Chr10:61401855-61442897 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017692
 protein coding gene Chr10:64027136-64068359 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015382
 protein coding gene Chr10:56888762-56928220 (-)
CAST/EiJ MGP_CASTEiJ_G0016628
 protein coding gene Chr10:61447773-61488797 (-)
CBA/J MGP_CBAJ_G0017029
 protein coding gene Chr10:66427099-66468609 (-)
DBA/2J MGP_DBA2J_G0017134
 protein coding gene Chr10:59192809-59232406 (-)
FVB/NJ MGP_FVBNJ_G0017128
 protein coding gene Chr10:58455506-58497372 (-)
LP/J MGP_LPJ_G0017208
 protein coding gene Chr10:62196571-62238509 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017156
 protein coding gene Chr10:68657168-68699131 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017730
 protein coding gene Chr10:61319486-61360865 (-)
PWK/PhJ MGP_PWKPhJ_G0016411
 protein coding gene Chr10:59056209-59096329 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016193
 protein coding gene Chr10:60688696-60732183 (-)
WSB/EiJ MGP_WSBEiJ_G0016692
 protein coding gene Chr10:61254822-61296260 (-)



Homology
more
  • Human Ortholog
    HKDC1, hexokinase domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HKDC1, hexokinase domain containing 1
  • Synonyms
    RP92
  • Links
    NCBI Gene ID: 80201
    neXtProt AC: NX_Q2TB90
    UniProt: Q2TB90

  • Chr Location
    10q22.1; chr10:69220332-69267552 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HKDC1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 4 alleles in 5 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lethality prior to genotyping. Mice heterozygous for a knock-out allele exhibit impaired glucose tolerance and female-specific increases in hepatic triglyceride levels. Some homozygous knockouts are viable but suffer from progressive retinal degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1110
  • Tissues
    127
  • cDNA Data
    15
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020080 Ensembl Gene Model | MGI Sequence Detail 39355 C57BL/6J ±  kb
    transcript ENSMUST00000020277 Ensembl | MGI Sequence Detail 3517 Not Applicable  
    polypeptide ENSMUSP00000020277 Ensembl | MGI Sequence Detail 915 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 16
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 7
      Gene Ontology 11
      Phenotypes 19
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345253 Zhang Y, et al., HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression. Nat Commun. 2024 Feb 13;15(1):1314
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory