Cybc1 MGI Mouse Gene Detail - MGI:2384959 - cytochrome b 245 chaperone 1

Symbol

Cybc1
Name

cytochrome b 245 chaperone 1
Synonyms

BC017643, MGC:28978, MGC:37062, MGC:37382

Feature Type

protein coding gene
IDs

MGI:2384959
NCBI Gene: 217370
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:121113414-121120135 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 85.10 cM
Mapping Data

2 experiments

SNPs within 2kb

268 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384959	protein coding gene	Chr11:121113414-121120148 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019543	protein coding gene	Chr11:125759034-125766191 (-)
A/J	MGP_AJ_G0019510	protein coding gene	Chr11:120140835-120147567 (-)
AKR/J	MGP_AKRJ_G0019480	protein coding gene	Chr11:123782266-123788368 (-)
BALB/cJ	MGP_BALBcJ_G0019485	protein coding gene	Chr11:120511276-120518005 (-)
C3H/HeJ	MGP_C3HHeJ_G0019291	protein coding gene	Chr11:124106079-124113496 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019934	protein coding gene	Chr11:129573689-129580423 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017559	protein coding gene	Chr11:117125822-117132736 (-)
CAST/EiJ	MGP_CASTEiJ_G0018845	protein coding gene	Chr11:125612429-125618535 (-)
CBA/J	MGP_CBAJ_G0019262	protein coding gene	Chr11:134607055-134613789 (-)
DBA/2J	MGP_DBA2J_G0019375	protein coding gene	Chr11:119511613-119518343 (-)
FVB/NJ	MGP_FVBNJ_G0019366	protein coding gene	Chr11:119229803-119236537 (-)
LP/J	MGP_LPJ_G0019446	protein coding gene	Chr11:126037804-126044532 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019399	protein coding gene	Chr11:133421727-133428459 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019973	protein coding gene	Chr11:124462659-124469393 (-)
PWK/PhJ	MGP_PWKPhJ_G0018612	protein coding gene	Chr11:120954827-120961765 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018403	protein coding gene	Chr11:124219243-124225953 (-)
WSB/EiJ	MGP_WSBEiJ_G0018898	protein coding gene	Chr11:124435226-124441936 (-)

Human Ortholog

CYBC1, cytochrome b-245 chaperone 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CYBC1, cytochrome b-245 chaperone 1
Synonyms

C17orf62, CGD5, Eros
Links

HGNC:28672

NCBI Gene ID: 79415

neXtProt AC: NX_Q9BQA9

UniProt: Q9BQA9
Chr Location

17q25.3; chr17:82440912-82450829 (-) GRCh38

MGI Vertebrate Homology

Cybc1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CYBC1
Gene Tree

Cybc1

Diseases

1 with human CYBC1 associations

				Human Disease	Mouse Models
				autosomal recessive chronic granulomatous disease 5 IDs autosomal recessive chronic granulomatous disease 5 DOID:0070368 OMIM:618935

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Gene trapped

1
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

17

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cybc1

ZFIN cybc1

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All Sequences

72
RefSeq

10
UniProt

4
CCDS

CCDS25771.1

Ensembl

ENSMUSG00000039294 (Evidence)
NCBI Gene

217370

			Length	Strain/Species	Flank
genomic	217370	NCBI Gene Model \| MGI Sequence Detail	6722	C57BL/6J	± kb
transcript	NM_144832	RefSeq \| MGI Sequence Detail	2483	C57BL/6
polypeptide	Q3TYS2	UniProt \| EBI \| MGI Sequence Detail	187	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000060039 cytochrome b-245 chaperone 1

(term hierarchy)
InterPro Domains

IPR027846 Cytochrome b-245 chaperone 1

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All nucleic 18

cDNA 18

Microarray probesets 4

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MGI:6156366

Summaries

All 35

Gene Ontology 4

Phenotypes 12
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cybc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112454	Chr11:121120119-121120140 (-)	5 bp
Tssr112453	Chr11:121120052-121120118 (-)	50 bp
Tssr112452	Chr11:121119864-121119929 (-)	238 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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