Flvcr2 MGI Mouse Gene Detail - MGI:2384974 - feline leukemia virus subgroup C cellular receptor 2

Symbol

Flvcr2
Name

feline leukemia virus subgroup C cellular receptor 2
Synonyms

CCT, Mfsd7c, MGC:19050

Feature Type

protein coding gene
IDs

MGI:2384974
NCBI Gene: 217721
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr12:85793313-85860359 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 39.80 cM
Mapping Data

2 experiments

SNPs within 2kb

1900 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384974	protein coding gene	Chr12:85793313-85860359 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019964	protein coding gene	Chr12:86546605-86620398 (+)
A/J	MGP_AJ_G0019921	protein coding gene	Chr12:83256261-83325323 (+)
AKR/J	MGP_AKRJ_G0019897	protein coding gene	Chr12:85509100-85578047 (+)
BALB/cJ	MGP_BALBcJ_G0019901	protein coding gene	Chr12:83595109-83663249 (+)
C3H/HeJ	MGP_C3HHeJ_G0019707	protein coding gene	Chr12:85990443-86062542 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020352	protein coding gene	Chr12:89042531-89112780 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017970	protein coding gene	Chr12:80146462-80216810 (+)
CAST/EiJ	MGP_CASTEiJ_G0019257	protein coding gene	Chr12:80975077-81045423 (+)
CBA/J	MGP_CBAJ_G0019678	protein coding gene	Chr12:92453862-92538220 (+)
DBA/2J	MGP_DBA2J_G0019792	protein coding gene	Chr12:82769100-82836908 (+)
FVB/NJ	MGP_FVBNJ_G0019779	protein coding gene	Chr12:81738378-81806805 (+)
LP/J	MGP_LPJ_G0019866	protein coding gene	Chr12:86424647-86496328 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019818	protein coding gene	Chr12:95281625-95354081 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020385	protein coding gene	Chr12:85123038-85193164 (+)
PWK/PhJ	MGP_PWKPhJ_G0019020	protein coding gene	Chr12:77285971-77354921 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018816	protein coding gene	Chr12:79610001-79682344 (+)
WSB/EiJ	MGP_WSBEiJ_G0019309	protein coding gene	Chr12:85864785-85935545 (+)

Human Ortholog

FLVCR2, FLVCR choline and putative heme transporter 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FLVCR2, FLVCR choline and putative heme transporter 2
Synonyms

C14orf58, CCT, EPV, FLVCRL14q, MFSD7C, PVHH, SLC49A2
Links

HGNC:20105

NCBI Gene ID: 55640

neXtProt AC: NX_Q9UPI3

UniProt: Q9UPI3
Chr Location

14q24.3; chr14:75578620-75663214 (+) GRCh38

MGI Vertebrate Homology

Flvcr2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FLVCR2
Gene Tree

Flvcr2

Diseases

1 with Flvcr2 mouse models; 1 with human FLVCR2 associations

Human Disease

Mouse Models

proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

34 phenotypes from 3 alleles in 2 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

2
Targeted

7
Genomic Mutations

1 involving Flvcr2
Incidental Mutations

APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit neonatal lethality, cyanosis, and impaired brain vasculature development.

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All GO Annotations

40
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

7
cDNA Data

32
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase flvcr2

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All Sequences

38
RefSeq

4
UniProt

3
CCDS

CCDS26062.1

Ensembl

ENSMUSG00000034258 (Evidence)
NCBI Gene

217721

			Length	Strain/Species	Flank
genomic	217721	NCBI Gene Model \| MGI Sequence Detail	67047	C57BL/6J	± kb
transcript	NM_145447	RefSeq \| MGI Sequence Detail	3435	C57BL/6
polypeptide	Q91X85	UniProt \| EBI \| MGI Sequence Detail	551	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007567 heme transporter FLVCR2

(term hierarchy)
PDB

8VZN, 8VZO
InterPro Domains

IPR011701 Major facilitator superfamily

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily

IPR049680 Solute carrier family 49-like

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All nucleic 32

cDNA 32

Microarray probesets 3

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MGI:5906163

Summaries

All 48

Developmental Gene Expression 5

Diseases 1

Gene Ontology 10

Phenotypes 19
Earliest

J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
Latest

J:354659 Wang H, et al., MFSD7C protects hemolysis-induced lung impairments by inhibiting ferroptosis. Nat Commun. 2024 Sep 19;15(1):8226

TSS for Flvcr2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114429	Chr12:85793314-85793325 (+)	7 bp
Tssr114430	Chr12:85793326-85793346 (+)	23 bp
Tssr114431	Chr12:85793348-85793378 (+)	50 bp
Tssr114432	Chr12:85806285-85806311 (+)	12,985 bp
Tssr114433	Chr12:85821589-85821604 (+)	28,284 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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