Cdca7l MGI Mouse Gene Detail - MGI:2384982 - cell division cycle associated 7 like

Symbol

Cdca7l
Name

cell division cycle associated 7 like
Synonyms

JPO2, MGC:11998

Feature Type

protein coding gene
IDs

MGI:2384982
NCBI Gene: 217946
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr12:117807209-117842441 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 63.20 cM
Mapping Data

2 experiments

SNPs within 2kb

1270 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384982	protein coding gene	Chr12:117768024-117842441 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020185	protein coding gene	Chr12:120781287-120820723 (+)
A/J	MGP_AJ_G0020141	protein coding gene	Chr12:116328543-116363191 (+)
AKR/J	MGP_AKRJ_G0020116	protein coding gene	Chr12:119855133-119891841 (+)
BALB/cJ	MGP_BALBcJ_G0020124	protein coding gene	Chr12:116750607-116785898 (+)
C3H/HeJ	MGP_C3HHeJ_G0019928	protein coding gene	Chr12:120141605-120177669 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020571	protein coding gene	Chr12:124558259-124598706 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018183	protein coding gene	Chr12:112722465-112755939 (+)
CAST/EiJ	MGP_CASTEiJ_G0019468	protein coding gene	Chr12:113997034-114036707 (+)
CBA/J	MGP_CBAJ_G0019895	protein coding gene	Chr12:129468077-129504672 (+)
DBA/2J	MGP_DBA2J_G0020012	protein coding gene	Chr12:115727212-115763844 (+)
FVB/NJ	MGP_FVBNJ_G0019997	protein coding gene	Chr12:114397776-114433911 (+)
LP/J	MGP_LPJ_G0020086	protein coding gene	Chr12:120813182-120851439 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020033	protein coding gene	Chr12:132727151-132765769 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020600	protein coding gene	Chr12:119022127-119060337 (+)
PWK/PhJ	MGP_PWKPhJ_G0019230	protein coding gene	Chr12:110478096-110516680 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019035	protein coding gene	Chr12:111987347-112021827 (+)
WSB/EiJ	MGP_WSBEiJ_G0019526	protein coding gene	Chr12:120005207-120042307 (+)

Human Ortholog

CDCA7L, cell division cycle associated 7 like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDCA7L, cell division cycle associated 7 like
Synonyms

JPO2, R1, RAM2
Links

HGNC:30777

NCBI Gene ID: 55536

neXtProt AC: NX_Q96GN5

UniProt: Q96GN5
Chr Location

7p15.3; chr7:21900899-21945903 (-) GRCh38

MGI Vertebrate Homology

Cdca7l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDCA7L
Gene Tree

Cdca7l

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Targeted

4
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

991
Tissues

38
cDNA Data

47
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CDCA7L

Xenbase cdca7l

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All Sequences

46
RefSeq

12
UniProt

3
CCDS

CCDS49197.1

Ensembl

ENSMUSG00000021175 (Evidence)
NCBI Gene

217946

			Length	Strain/Species	Flank
genomic	217946	NCBI Gene Model \| MGI Sequence Detail	35233	C57BL/6J	± kb
transcript	NR_182072	RefSeq \| MGI Sequence Detail	2752	C57BL/6
polypeptide	Q922M5	UniProt \| EBI \| MGI Sequence Detail	438	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005225 cell division cycle-associated 7-like protein

(term hierarchy)
InterPro Domains

IPR040221 CDCA7/CDA7L

IPR018866 Zinc-finger domain of monoamine-oxidase A repressor R1
GlyGen

Q922M5 1 site, 1 N-linked glycan (1 site)

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All nucleic 47

cDNA 47

Microarray probesets 3

Summaries

All 34

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 5
Earliest

J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cdca7l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr3984	Chr12:117807175-117807209 (+)	-17 bp
Tssr115551	Chr12:117807224-117807242 (+)	24 bp
Tssr115552	Chr12:117807429-117807475 (+)	243 bp
Tssr115553	Chr12:117807581-117807606 (+)	385 bp
Tssr115554	Chr12:117807608-117807658 (+)	424 bp
Tssr115555	Chr12:117828644-117828672 (+)	21,449 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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