Paip1 MGI Mouse Gene Detail - MGI:2384993 - polyadenylate binding protein-interacting protein 1

Symbol

Paip1
Name

polyadenylate binding protein-interacting protein 1

Feature Type

protein coding gene
IDs

MGI:2384993
NCBI Gene: 218693
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr13:119565137-119594754 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 67.22 cM
Mapping Data

2 experiments

SNPs within 2kb

750 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384993	protein coding gene	Chr13:119564960-119596858 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020970	protein coding gene	Chr13:122446162-122481139 (+)
A/J	MGP_AJ_G0020920	protein coding gene	Chr13:117481636-117519562 (+)
AKR/J	MGP_AKRJ_G0020895	protein coding gene	Chr13:120961091-120994646 (+)
BALB/cJ	MGP_BALBcJ_G0020920	protein coding gene	Chr13:118161740-118190709 (+)
C3H/HeJ	MGP_C3HHeJ_G0020709	protein coding gene	Chr13:120777999-120810041 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021356	protein coding gene	Chr13:126022265-126051825 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018925	protein coding gene	Chr13:112471447-112499237 (+)
CAST/EiJ	MGP_CASTEiJ_G0020228	protein coding gene	Chr13:120641102-120677901 (+)
CBA/J	MGP_CBAJ_G0020671	protein coding gene	Chr13:130861596-130900396 (+)
DBA/2J	MGP_DBA2J_G0020794	protein coding gene	Chr13:117097592-117127550 (+)
FVB/NJ	MGP_FVBNJ_G0020778	protein coding gene	Chr13:115694604-115724005 (+)
LP/J	MGP_LPJ_G0020870	protein coding gene	Chr13:122411607-122445980 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020806	protein coding gene	Chr13:131501289-131535264 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021392	protein coding gene	Chr13:120466043-120505274 (+)
PWK/PhJ	MGP_PWKPhJ_G0019981	protein coding gene	Chr13:115982771-116013794 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019804	protein coding gene	Chr13:116844217-116876367 (+)
WSB/EiJ	MGP_WSBEiJ_G0020286	protein coding gene	Chr13:121144878-121177251 (+)

Human Ortholog

PAIP1, poly(A) binding protein interacting protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PAIP1, poly(A) binding protein interacting protein 1
Links

HGNC:16945

NCBI Gene ID: 10605

neXtProt AC: NX_Q9H074

UniProt: Q9H074
Chr Location

5p12; chr5:43526267-43557758 (-) GRCh38

MGI Vertebrate Homology

Paip1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PAIP1
Gene Tree

Paip1

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Endonuclease-mediated

1
Gene trapped

27
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

55 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

18
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

14
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase paip1

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All Sequences

66
RefSeq

4
UniProt

7
CCDS

CCDS26796.1, CCDS36791.1

Ensembl

ENSMUSG00000025451 (Evidence)
NCBI Gene

218693

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025451	Ensembl Gene Model \| MGI Sequence Detail	29618	C57BL/6J	± kb
transcript	ENSMUST00000126957	Ensembl \| MGI Sequence Detail	1731	Not Applicable
polypeptide	ENSMUSP00000117256	Ensembl \| MGI Sequence Detail	484	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000012236 polyadenylate-binding protein-interacting protein 1

(term hierarchy)
InterPro Domains

IPR016024 Armadillo-type fold

IPR009818 Ataxin-2, C-terminal

IPR003890 MIF4G-like, type 3

IPR051367 mRNA Translation Regulation/Replication-dependent Histone mRNA Translation
GlyGen

Q8VE62 1 site, 1 N-linked glycan (1 site)

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All nucleic 15

cDNA 14

Primer pair 1

Microarray probesets 8

Summaries

All 39

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 11
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Paip1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121251	Chr13:119564918-119564921 (+)	-217 bp
Tssr121252	Chr13:119564932-119564949 (+)	-196 bp
Tssr121253	Chr13:119564952-119564982 (+)	-170 bp
Tssr121254	Chr13:119564985-119565021 (+)	-134 bp
Tssr121255	Chr13:119565026-119565040 (+)	-104 bp
Tssr121256	Chr13:119565097-119565111 (+)	-33 bp
Tssr121257	Chr13:119565119-119565148 (+)	-3 bp
Tssr121258	Chr13:119565424-119565496 (+)	323 bp
Tssr121259	Chr13:119565801-119565808 (+)	668 bp
Tssr121260	Chr13:119566205-119566216 (+)	1,074 bp
Tssr121261	Chr13:119566251-119566266 (+)	1,122 bp
Tssr121262	Chr13:119593670-119593674 (+)	28,535 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24