Ube2e2 MGI Mouse Gene Detail - MGI:2384997 - ubiquitin-conjugating enzyme E2E 2

Symbol

Ube2e2
Name

ubiquitin-conjugating enzyme E2E 2
Synonyms

MGC:28917

Feature Type

protein coding gene
IDs

MGI:2384997
NCBI Gene: 218793
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr14:3575429-3896121 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 7.08 cM
Mapping Data

1 experiment

SNPs within 2kb

6191 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384997	protein coding gene	Chr14:3575429-3896133 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021022	protein coding gene	Chr14:11193737-11523810 (-)
A/J	MGP_AJ_G0020971	protein coding gene	Chr14:10880382-11195838 (-)
AKR/J	MGP_AKRJ_G0020948	protein coding gene	Chr14:11226535-11556847 (-)
BALB/cJ	MGP_BALBcJ_G0020974	protein coding gene	Chr14:10937078-11247818 (-)
C3H/HeJ	MGP_C3HHeJ_G0020758	protein coding gene	Chr14:11261633-11603763 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021407	protein coding gene	Chr14:11607311-11943688 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018976	protein coding gene	Chr14:11365578-11666545 (-)
CAST/EiJ	MGP_CASTEiJ_G0020281	protein coding gene	Chr14:11140311-11460603 (-)
CBA/J	MGP_CBAJ_G0020724	protein coding gene	Chr14:12102084-12432314 (-)
DBA/2J	MGP_DBA2J_G0020847	protein coding gene	Chr14:10773245-11093913 (-)
FVB/NJ	MGP_FVBNJ_G0020830	protein coding gene	Chr14:10646150-10959040 (-)
LP/J	MGP_LPJ_G0020923	protein coding gene	Chr14:11249957-11586121 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020856	protein coding gene	Chr14:11975734-12358873 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021439	protein coding gene	Chr14:11094402-11419074 (-)
PWK/PhJ	MGP_PWKPhJ_G0020032	protein coding gene	Chr14:10811339-11124178 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019852	protein coding gene	Chr14:11208346-11545703 (-)
WSB/EiJ	MGP_WSBEiJ_G0020337	protein coding gene	Chr14:11125595-11453057 (-)

Human Ortholog

UBE2E2, ubiquitin conjugating enzyme E2 E2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UBE2E2, ubiquitin conjugating enzyme E2 E2
Synonyms

UBCH8
Links

HGNC:12478

NCBI Gene ID: 7325

neXtProt AC: NX_Q96LR5

UniProt: Q96LR5
Chr Location

3p24.3; chr3:23203020-23591925 (+) GRCh38

MGI Vertebrate Homology

Ube2e2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UBE2E2
Gene Tree

Ube2e2

Diseases

1 with human UBE2E2 associations

				Human Disease	Mouse Models
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Gene trapped

1
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

14 strains or lines available

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All GO Annotations

22
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

808
Tissues

34
cDNA Data

25
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ube2e2

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All Sequences

84
RefSeq

25
UniProt

6
CCDS

CCDS26838.1

Ensembl

ENSMUSG00000058317 (Evidence)
NCBI Gene

218793

			Length	Strain/Species	Flank
genomic	ENSMUSG00000058317	Ensembl Gene Model \| MGI Sequence Detail	320693	C57BL/6J	± kb
transcript	ENSMUST00000076133	Ensembl \| MGI Sequence Detail	606	Not Applicable
polypeptide	ENSMUSP00000075495	Ensembl \| MGI Sequence Detail	201	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000016972 ubiquitin-conjugating enzyme E2 E2

(term hierarchy)
EC

2.3.2.23
InterPro Domains

IPR023313 Ubiquitin-conjugating enzyme, active site

IPR000608 Ubiquitin-conjugating enzyme E2

IPR016135 Ubiquitin-conjugating enzyme/RWD-like

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All nucleic 26

cDNA 26

Microarray probesets 2

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 10
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345911 Sakurai Y, et al., Overexpression of UBE2E2 in Mouse Pancreatic beta-Cells Leads to Glucose Intolerance via Reduction of beta-Cell Mass. Diabetes. 2024 Mar 1;73(3):474-489

TSS for Ube2e2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr127544	Chr14:3575414-3575441 (+)	-1 bp
Tssr127543	Chr14:3575880-3575947 (+)	485 bp
Tssr127542	Chr14:3575979-3576032 (+)	577 bp
Tssr127541	Chr14:3576049-3576073 (+)	632 bp
Tssr127540	Chr14:3576276-3576320 (+)	869 bp
Tssr127539	Chr14:3600726-3600742 (+)	25,305 bp
Tssr127538	Chr14:3652784-3652796 (+)	77,361 bp
Tssr127537	Chr14:3760021-3760049 (+)	184,606 bp
Tssr127535	Chr14:3804540-3804556 (+)	229,119 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24