Pprc1 MGI Mouse Gene Detail - MGI:2385096 - peroxisome proliferative activated receptor, gamma, coactivator-related 1

Symbol

Pprc1
Name

peroxisome proliferative activated receptor, gamma, coactivator-related 1
Synonyms

MGC:12121, mKIAA0595

Feature Type

protein coding gene
IDs

MGI:2385096
NCBI Gene: 226169
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr19:46044955-46061348 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 38.75 cM
Mapping Data

3 experiments

SNPs within 2kb

483 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385096	protein coding gene	Chr19:46033325-46061354 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025198	protein coding gene	Chr19:45703557-45735137 (+)
A/J	MGP_AJ_G0025174	protein coding gene	Chr19:43457420-43485809 (+)
AKR/J	MGP_AKRJ_G0025143	protein coding gene	Chr19:44862470-44894142 (+)
BALB/cJ	MGP_BALBcJ_G0025169	protein coding gene	Chr19:43513308-43540890 (+)
C3H/HeJ	MGP_C3HHeJ_G0024929	protein coding gene	Chr19:45036020-45064447 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025612	protein coding gene	Chr19:46841109-46871125 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023026	protein coding gene	Chr19:42693525-42725594 (+)
CAST/EiJ	MGP_CASTEiJ_G0024394	protein coding gene	Chr19:44805983-44840421 (+)
CBA/J	MGP_CBAJ_G0024909	protein coding gene	Chr19:49198186-49234415 (+)
DBA/2J	MGP_DBA2J_G0025041	protein coding gene	Chr19:43275642-43306315 (+)
FVB/NJ	MGP_FVBNJ_G0025002	protein coding gene	Chr19:43051551-43080765 (+)
LP/J	MGP_LPJ_G0025127	protein coding gene	Chr19:45613033-45643463 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025033	protein coding gene	Chr19:48560146-48589240 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025670	protein coding gene	Chr19:44970421-45001068 (+)
PWK/PhJ	MGP_PWKPhJ_G0024143	protein coding gene	Chr19:43206431-43236088 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023947	protein coding gene	Chr19:43625919-43659488 (+)
WSB/EiJ	MGP_WSBEiJ_G0024464	protein coding gene	Chr19:45115582-45143720 (+)

Human Ortholog

PPRC1, PPARG related coactivator 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPRC1, PPARG related coactivator 1
Synonyms

PRC
Links

HGNC:30025

NCBI Gene ID: 23082

neXtProt AC: NX_Q5VV67

UniProt: Q5VV67
Chr Location

10q24.32; chr10:102119889-102150333 (+) GRCh38

MGI Vertebrate Homology

Pprc1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PPRC1
Gene Tree

Pprc1

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

50
Endonuclease-mediated

2
Gene trapped

43
Targeted

5
Genomic Mutations

1 involving Pprc1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

98 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit letahlity post-implantation with delayed hatching and disorganized embryo tissues.

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All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

739
Tissues

33
cDNA Data

118
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pprc1

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All Sequences

87
RefSeq

32
UniProt

5
CCDS

CCDS38005.1, CCDS89404.1

Ensembl

ENSMUSG00000055491 (Evidence)
NCBI Gene

226169

			Length	Strain/Species	Flank
genomic	226169	NCBI Gene Model \| MGI Sequence Detail	16394	C57BL/6J	± kb
transcript	NM_001346801	RefSeq \| MGI Sequence Detail	5250	C57BL/6
polypeptide	Q6NZN1	UniProt \| EBI \| MGI Sequence Detail	1644	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000013159 peroxisome proliferator-activated receptor gamma coactivator-related protein 1

(term hierarchy)
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR034605 PGC-1

IPR034834 PGC-1-related coactivator, RNA recognition motif

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain
GlyGen

Q6NZN1 1 site, 1 O-linked glycan (1 site)

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All nucleic 120

cDNA 118

Primer pair 2

Microarray probesets 3

Summaries

All 45

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 13
Earliest

J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
Latest

J:244174 Alkaissi H, et al., Genome-Wide Association Study to Identify Genes Related to Renal Mercury Concentrations in Mice. Environ Health Perspect. 2016 Jul;124(7):920-6

TSS for Pprc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156704	Chr19:46044993-46045025 (+)	54 bp
Tssr156705	Chr19:46045725-46045750 (+)	783 bp
Tssr156706	Chr19:46052518-46052526 (+)	7,567 bp
Tssr156707	Chr19:46052594-46052613 (+)	7,649 bp
Tssr156708	Chr19:46052860-46052864 (+)	7,907 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24