Lrrc26 MGI Mouse Gene Detail - MGI:2385129 - leucine rich repeat containing 26

Symbol

Lrrc26
Name

leucine rich repeat containing 26
Synonyms

MGC:37548, MGC:37592, MGC:6965

Feature Type

protein coding gene
IDs

MGI:2385129
NCBI Gene: 227618
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:25179927-25181192 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 17.14 cM
Mapping Data

2 experiments

SNPs within 2kb

52 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385129	protein coding gene	Chr2:25179923-25181205 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025437	protein coding gene	Chr2:23157786-23159051 (+)
A/J	MGP_AJ_G0025414	protein coding gene	Chr2:22269207-22270472 (+)
AKR/J	MGP_AKRJ_G0025384	protein coding gene	Chr2:23014657-23015922 (+)
BALB/cJ	MGP_BALBcJ_G0025410	protein coding gene	Chr2:22380396-22381661 (+)
C3H/HeJ	MGP_C3HHeJ_G0025171	protein coding gene	Chr2:22940378-22941643 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025854	protein coding gene	Chr2:23892512-23893777 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023265	protein coding gene	Chr2:21185373-21186640 (+)
CAST/EiJ	MGP_CASTEiJ_G0024635	protein coding gene	Chr2:22823849-22825114 (+)
CBA/J	MGP_CBAJ_G0025149	protein coding gene	Chr2:24729528-24730793 (+)
DBA/2J	MGP_DBA2J_G0025282	protein coding gene	Chr2:22110807-22112072 (+)
FVB/NJ	MGP_FVBNJ_G0025244	protein coding gene	Chr2:21851790-21853055 (+)
LP/J	MGP_LPJ_G0025368	protein coding gene	Chr2:23102325-23103590 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025275	protein coding gene	Chr2:24930413-24931678 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025913	protein coding gene	Chr2:22960694-22961959 (+)
PWK/PhJ	MGP_PWKPhJ_G0024383	protein coding gene	Chr2:21924007-21925272 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024183	protein coding gene	Chr2:23115370-23116635 (+)
WSB/EiJ	MGP_WSBEiJ_G0024703	protein coding gene	Chr2:23031219-23032484 (+)

Human Ortholog

LRRC26, leucine rich repeat containing 26

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LRRC26, leucine rich repeat containing 26
Synonyms

bA350O14.10, CAPC
Links

HGNC:31409

NCBI Gene ID: 389816

neXtProt AC: NX_Q2I0M4

UniProt: Q2I0M4
Chr Location

9q34.3

MGI Vertebrate Homology

Lrrc26 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: LRRC26
Gene Tree

Lrrc26

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Targeted

2
Incidental Mutations

CvDC
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

The gene product is part of BK ion channels in secretory epithelial cells. Homozygous knockout results in significantly reduced K+ efflux from salivary glands.

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All GO Annotations

20
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

33

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

34
RefSeq

2
UniProt

1
CCDS

CCDS15763.1

Ensembl

ENSMUSG00000026961 (Evidence)
NCBI Gene

227618

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026961	Ensembl Gene Model \| MGI Sequence Detail	1266	C57BL/6J	± kb
transcript	ENSMUST00000028337	Ensembl \| MGI Sequence Detail	1190	Not Applicable
polypeptide	ENSMUSP00000028337	Ensembl \| MGI Sequence Detail	331	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000032092 leucine-rich repeat-containing protein 26

(term hierarchy)
InterPro Domains

IPR000483 Cysteine-rich flanking region, C-terminal

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR051432 Voltage and calcium-activated potassium channel auxiliary protein

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All nucleic 33

cDNA 33

Microarray probesets 3

Summaries

All 31

Gene Ontology 6

Phenotypes 5
Earliest

J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
Latest

J:300474 Gonzalez-Perez V, et al., Goblet cell LRRC26 regulates BK channel activation and protects against colitis in mice. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2019149118

TSS for Lrrc26:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16696	Chr2:25179911-25179947 (+)	2 bp
Tssr430	Chr2:25179963-25179973 (+)	41 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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