Gdap1l1 Gene Detail

Summary

• Symbol
  Gdap1l1
• Name
  ganglioside-induced differentiation-associated protein 1-like 1
• Synonyms
  MGC:28116

• Feature Type
  protein coding gene
• IDs
  MGI:2385163
  NCBI Gene: 228858
• Alliance
  gene page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  Chr2:163280396-163297244 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 2, 84.28 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  490 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385163	protein coding gene	Chr2:163280387-163297264 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026822	protein coding gene	Chr2:168785772-168802562 (+)
A/J	MGP_AJ_G0026788	protein coding gene	Chr2:161987268-162004013 (+)
AKR/J	MGP_AKRJ_G0026759	protein coding gene	Chr2:166776199-166792973 (+)
BALB/cJ	MGP_BALBcJ_G0026797	protein coding gene	Chr2:162311208-162327973 (+)
C3H/HeJ	MGP_C3HHeJ_G0026539	protein coding gene	Chr2:167122437-167141972 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027245	protein coding gene	Chr2:173717547-173734398 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024615	protein coding gene	Chr2:155281098-155298066 (+)
CAST/EiJ	MGP_CASTEiJ_G0026000	protein coding gene	Chr2:167510130-167528528 (+)
CBA/J	MGP_CBAJ_G0026516	protein coding gene	Chr2:180001815-180018585 (+)
DBA/2J	MGP_DBA2J_G0026654	protein coding gene	Chr2:161150816-161167606 (+)
FVB/NJ	MGP_FVBNJ_G0026620	protein coding gene	Chr2:159526435-159543285 (+)
LP/J	MGP_LPJ_G0026757	protein coding gene	Chr2:168919230-168936096 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026642	protein coding gene	Chr2:183654223-183671068 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027301	protein coding gene	Chr2:166658808-166675738 (+)
PWK/PhJ	MGP_PWKPhJ_G0025734	protein coding gene	Chr2:160710247-160727049 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025537	protein coding gene	Chr2:165535639-165551993 (+)
WSB/EiJ	MGP_WSBEiJ_G0026070	protein coding gene	Chr2:167518462-167535303 (+)

Homology

• Human Ortholog
  GDAP1L1, ganglioside induced differentiation associated protein 1 like 1

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  GDAP1L1, ganglioside induced differentiation associated protein 1 like 1
  
• Synonyms
  dJ881L22.1, dJ995J12.1.1
• Links
  HGNC:4213

  NCBI Gene ID: 78997

  neXtProt AC: NX_Q96MZ0

  UniProt: Q96MZ0

  
  
• Chr Location
  20q13.12; chr20:44247099-44280947 (+)  GRCh38

---

• MGI Vertebrate Homology
  Gdap1l1 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: GDAP1L1
• Gene Tree
  Gdap1l1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotype references
  

• All Mutations and Alleles
  4
• Endonuclease-mediated
  1
• Gene trapped
  1
• Targeted
  2
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  18 strains or lines available

Expression

• Assay Results
  819
• Tissues
  19
• cDNA Data
  25
• Literature Summary
  3

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase gdap1l1

Sequences &
Gene Models

• All Sequences
  44
• RefSeq
  6
• UniProt
  3
• CCDS
  CCDS50791.1

• Ensembl
  ENSMUSG00000017943 (Evidence)
• NCBI Gene
  228858

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000017943	Ensembl Gene Model | MGI Sequence Detail	16849	C57BL/6J
transcript	ENSMUST00000109421	Ensembl | MGI Sequence Detail	1206	Not Applicable
polypeptide	ENSMUSP00000105048	Ensembl | MGI Sequence Detail	370	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000007913 ganglioside-induced differentiation-associated protein 1-like 1
  (term hierarchy)
• InterPro Domains
  IPR036282 Glutathione S-transferase, C-terminal domain superfamily
  IPR010987 Glutathione S-transferase, C-terminal-like
  IPR004045 Glutathione S-transferase, N-terminal
  IPR040079 Glutathione transferase family
  IPR036249 Thioredoxin-like superfamily
• GlyGen
  Q8VE33 1 site, 1 O-linked glycan (1 site)

Molecular
Reagents

• All nucleic 25

  cDNA 25

  
  

  Microarray probesets 3

References

• Summaries
  All 22

  Developmental Gene Expression 3

  Phenotypes 4
• Earliest
  J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
• Latest
  J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Gdap1l1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21464	Chr2:163280375-163280456 (+)	20 bp
Tssr21465	Chr2:163280459-163280466 (+)	67 bp