About   Help   FAQ
Slc16a4 Gene Detail
Summary
  • Symbol
    Slc16a4
  • Name
    solute carrier family 16 (monocarboxylic acid transporters), member 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385183
    NCBI Gene: 229699
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:107198546-107219431 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 46.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    501 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385183
 protein coding gene Chr3:107198543-107219437 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027746
 protein coding gene Chr3:108771571-108792353 (+)
A/J MGP_AJ_G0027706
 protein coding gene Chr3:105326882-105347767 (+)
AKR/J MGP_AKRJ_G0027671
 protein coding gene Chr3:107902704-107923604 (+)
BALB/cJ MGP_BALBcJ_G0027718
 protein coding gene Chr3:105024776-105046141 (+)
C3H/HeJ MGP_C3HHeJ_G0027448
 protein coding gene Chr3:108243238-108264145 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028162
 protein coding gene Chr3:112849785-112870597 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025500
 protein coding gene Chr3:101490146-101511068 (+)
CAST/EiJ MGP_CASTEiJ_G0026904
 protein coding gene Chr3:107618158-107639940 (+)
CBA/J MGP_CBAJ_G0027423
 protein coding gene Chr3:116668548-116689376 (+)
DBA/2J MGP_DBA2J_G0027565
 protein coding gene Chr3:104529152-104550079 (+)
FVB/NJ MGP_FVBNJ_G0027533
 protein coding gene Chr3:102409124-102430224 (+)
LP/J MGP_LPJ_G0027672
 protein coding gene Chr3:110190010-110211481 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027563
 protein coding gene Chr3:122793949-122815226 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028217
 protein coding gene Chr3:107493136-107515176 (+)
PWK/PhJ MGP_PWKPhJ_G0026630
 protein coding gene Chr3:104255831-104276789 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026450
 protein coding gene Chr3:105625432-105646501 (+)
WSB/EiJ MGP_WSBEiJ_G0026984
 protein coding gene Chr3:108015475-108037202 (+)



Homology
more
  • Human Ortholog
    SLC16A4, solute carrier family 16 member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC16A4, solute carrier family 16 member 4
  • Synonyms
    MCT4, MCT5
  • Links
    NCBI Gene ID: 9122
    neXtProt AC: NX_O15374
    UniProt: O15374

  • Chr Location
    1p13.3; chr1:110362851-110391082 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    8
  • cDNA Data
    26
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027896 Ensembl Gene Model | MGI Sequence Detail 20886 C57BL/6J ±  kb
    transcript ENSMUST00000029502 Ensembl | MGI Sequence Detail 2248 Not Applicable  
    polypeptide ENSMUSP00000029502 Ensembl | MGI Sequence Detail 500 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 26
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139973
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:357567 Zhang Y, et al., Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation. Cell Rep. 2024 May 28;43(5):114180
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory