About   Help   FAQ
Gnl2 Gene Detail
Summary
  • Symbol
    Gnl2
  • Name
    guanine nucleotide binding protein nucleolar 2
  • Synonyms
    MGC:7863, Ngp-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385207
    NCBI Gene: 230737
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:124920866-124949175 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 57.97 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    576 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385207
 protein coding gene Chr4:124910378-124949175 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028761
 protein coding gene Chr4:126593256-126635455 (+)
A/J MGP_AJ_G0028720
 protein coding gene Chr4:121617158-121656773 (+)
AKR/J MGP_AKRJ_G0028673
 protein coding gene Chr4:124957269-124996946 (+)
BALB/cJ MGP_BALBcJ_G0028743
 protein coding gene Chr4:122199779-122249115 (+)
C3H/HeJ MGP_C3HHeJ_G0028457
 protein coding gene Chr4:125031176-125072900 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029185
 protein coding gene Chr4:131455157-131498379 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026458
 protein coding gene Chr4:114787041-114826328 (+)
CAST/EiJ MGP_CASTEiJ_G0027890
 protein coding gene Chr4:123104952-123147594 (+)
CBA/J MGP_CBAJ_G0028423
 protein coding gene Chr4:134737692-134780390 (+)
DBA/2J MGP_DBA2J_G0028572
 protein coding gene Chr4:122090329-122130167 (+)
FVB/NJ MGP_FVBNJ_G0028539
 protein coding gene Chr4:120720362-120758879 (+)
LP/J MGP_LPJ_G0028673
 protein coding gene Chr4:126879267-126920949 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028565
 protein coding gene Chr4:139712870-139755485 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029223
 protein coding gene Chr4:125307456-125348499 (+)
PWK/PhJ MGP_PWKPhJ_G0027611
 protein coding gene Chr4:118520890-118561573 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027437
 protein coding gene Chr4:121081751-121126232 (+)
WSB/EiJ MGP_WSBEiJ_G0027970
 protein coding gene Chr4:125386904-125429504 (+)



Homology
more
  • Human Ortholog
    GNL2, G protein nucleolar 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNL2, G protein nucleolar 2
  • Synonyms
    HUMAUANTIG, Ngp-1, NGP1, Nog2, Nug2
  • Links
    NCBI Gene ID: 29889
    neXtProt AC: NX_Q13823
    UniProt: Q13823

  • Chr Location
    1p34.3; chr1:37566816-37595937 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    6
  • cDNA Data
    107
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 230737 NCBI Gene Model | MGI Sequence Detail 28310 C57BL/6J ±  kb
    transcript NM_145552 RefSeq | MGI Sequence Detail 2350 C57BL/6  
    polypeptide Q99LH1 UniProt | EBI | MGI Sequence Detail 728 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000008116 nucleolar GTP-binding protein 2
      (term hierarchy)
    • InterPro Domains
      IPR030378 Circularly permuted (CP)-type guanine nucleotide-binding (G) domain
      IPR006073 GTP binding domain
      IPR023179 GTP-binding protein, orthogonal bundle domain superfamily
      IPR024929 Nucleolar GTP-binding protein 2, circularly permuted GTPase motif
      IPR012971 Nucleolar GTP-binding protein 2, N-terminal domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR050755 TRAFAC YlqF/YawG GTPases, Ribosome Maturation
    • GlyGen
      Q99LH1 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 107
      cDNA 107

      Microarray probesets 5
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory