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Tnrc6a Gene Detail
Summary
  • Symbol
    Tnrc6a
  • Name
    trinucleotide repeat containing 6a
  • Synonyms
    2010321I05Rik, 3110054G10Rik, CAGH26, D130023A07Rik, MGC:11932, Tnrc6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385292
    NCBI Gene: 233833
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:122723108-122794519 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 67.42 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1303 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385292
 protein coding gene Chr7:122630324-122794519 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032959
 protein coding gene Chr7:127261265-127333110 (+)
A/J MGP_AJ_G0032942
 protein coding gene Chr7:123950422-124022590 (+)
AKR/J MGP_AKRJ_G0032874
 protein coding gene Chr7:127110031-127182558 (+)
BALB/cJ MGP_BALBcJ_G0032947
 protein coding gene Chr7:123625465-123697774 (+)
C3H/HeJ MGP_C3HHeJ_G0032657
 protein coding gene Chr7:127000314-127089408 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033453
 protein coding gene Chr7:132228302-132302454 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030425
 protein coding gene Chr7:125244029-125316427 (+)
CAST/EiJ MGP_CASTEiJ_G0031985
 protein coding gene Chr7:118822300-118900369 (+)
CBA/J MGP_CBAJ_G0032630
 protein coding gene Chr7:136685751-136761198 (+)
DBA/2J MGP_DBA2J_G0032782
 protein coding gene Chr7:121937511-122009308 (+)
FVB/NJ MGP_FVBNJ_G0032735
 protein coding gene Chr7:121788064-121857906 (+)
LP/J MGP_LPJ_G0032876
 protein coding gene Chr7:128691504-128764179 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032767
 protein coding gene Chr7:138026039-138105230 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033473
 protein coding gene Chr7:126107877-126180432 (+)
PWK/PhJ MGP_PWKPhJ_G0031693
 protein coding gene Chr7:114880685-114953035 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031539
 protein coding gene Chr7:112883278-112954498 (+)
WSB/EiJ MGP_WSBEiJ_G0032098
 protein coding gene Chr7:127019704-127091011 (+)



Homology
more
  • Human Ortholog
    TNRC6A, trinucleotide repeat containing adaptor 6A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNRC6A, trinucleotide repeat containing adaptor 6A
  • Synonyms
    CAGH26, FAME6, GW1, GW182, TNRC6
  • Links
    NCBI Gene ID: 27327
    neXtProt AC: NX_Q8NDV7
    UniProt: Q8NDV7

  • Chr Location
    16p12.1; chr16:24610205-24827632 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TNRC6A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit partial embryonic lethality during organogenesis associated with impaired hematopoiesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    850
  • Tissues
    132
  • cDNA Data
    206
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052707 Ensembl Gene Model | MGI Sequence Detail 71412 C57BL/6J ±  kb
    transcript ENSMUST00000094053 Ensembl | MGI Sequence Detail 8183 Not Applicable  
    polypeptide ENSMUSP00000091595 Ensembl | MGI Sequence Detail 1896 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 214
      cDNA 206
      Primer pair 6
      Other 2

      Microarray probesets 12
    Other
    Accession IDs
    less
    MGI:1914559, MGI:1923945, MGI:2142265, MGI:2443163
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 12
      Gene Ontology 8
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:349837 Liu H, et al., A local translation program regulates centriole amplification in the airway epithelium. Sci Rep. 2023 May 1;13(1):7090
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory