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Map3k21 Gene Detail
Summary
  • Symbol
    Map3k21
  • Name
    mitogen-activated protein kinase kinase kinase 21
  • Synonyms
    BC021891, MGC:27778
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385307
    NCBI Gene: 234878
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:126637189-126674179 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 73.65 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1332 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385307
 protein coding gene Chr8:126637189-126674179 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034290
 protein coding gene Chr8:129705705-129742688 (+)
A/J MGP_AJ_G0034270
 protein coding gene Chr8:124323607-124360571 (+)
AKR/J MGP_AKRJ_G0034197
 protein coding gene Chr8:127888418-127925707 (+)
BALB/cJ MGP_BALBcJ_G0034263
 protein coding gene Chr8:124486560-124523539 (+)
C3H/HeJ MGP_C3HHeJ_G0033974
 protein coding gene Chr8:128542513-128580746 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034783
 protein coding gene Chr8:134014584-134051494 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031724
 protein coding gene Chr8:117052719-117092487 (+)
CAST/EiJ MGP_CASTEiJ_G0033301
 protein coding gene Chr8:128694899-128731759 (+)
CBA/J MGP_CBAJ_G0033947
 protein coding gene Chr8:138950276-138989437 (+)
DBA/2J MGP_DBA2J_G0034103
 protein coding gene Chr8:123465548-123502531 (+)
FVB/NJ MGP_FVBNJ_G0034047
 protein coding gene Chr8:122663193-122700905 (+)
LP/J MGP_LPJ_G0034192
 protein coding gene Chr8:129852104-129889071 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034094
 protein coding gene Chr8:140942834-140980039 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034802
 protein coding gene Chr8:128130987-128169965 (+)
PWK/PhJ MGP_PWKPhJ_G0033003
 protein coding gene Chr8:123230358-123266988 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032842
 protein coding gene Chr8:126760303-126799118 (+)
WSB/EiJ MGP_WSBEiJ_G0033418
 protein coding gene Chr8:128863620-128900634 (+)



Homology
more
  • Human Ortholog
    MAP3K21, mitogen-activated protein kinase kinase kinase 21
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP3K21, mitogen-activated protein kinase kinase kinase 21
  • Synonyms
    dJ862P8.3, MLK4
  • Links
    NCBI Gene ID: 84451
    neXtProt AC: NX_Q5TCX8
    UniProt: Q5TCX8

  • Chr Location
    1q42.2; chr1:233327724-233385148 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    4
  • cDNA Data
    14
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 234878 NCBI Gene Model | MGI Sequence Detail 36991 C57BL/6J ±  kb
transcript NM_145608 RefSeq | MGI Sequence Detail 5692 Not Specified  
polypeptide Q8VDG6 UniProt | EBI | MGI Sequence Detail 1002 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 14
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 25
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 2
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:156788 Bouma GJ, et al., New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation. Biol Reprod. 2010 Feb;82(2):380-9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory