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Fras1 Gene Detail
Summary
  • Symbol
    Fras1
  • Name
    Fraser extracellular matrix complex subunit 1
  • Synonyms
    bl, E130113P14Rik, mKIAA1500
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385368
    NCBI Gene: 231470
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:96521814-96932587 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 47.29 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12216 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385368
 protein coding gene Chr5:96518622-96932592 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029765
 protein coding gene Chr5:97596667-98029888 (+)
A/J MGP_AJ_G0029731
 protein coding gene Chr5:94018847-94428692 (+)
AKR/J MGP_AKRJ_G0029677
 protein coding gene Chr5:97165014-97586992 (+)
BALB/cJ MGP_BALBcJ_G0029741
 protein coding gene Chr5:95031112-95437130 (+)
C3H/HeJ MGP_C3HHeJ_G0029464
 protein coding gene Chr5:97485533-97910502 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030196
 protein coding gene Chr5:101760564-102194311 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027431
 protein coding gene Chr5:89414600-89810354 (+)
CAST/EiJ MGP_CASTEiJ_G0028874
 protein coding gene Chr5:96064231-96503627 (+)
CBA/J MGP_CBAJ_G0029434
 protein coding gene Chr5:105275760-105720761 (+)
DBA/2J MGP_DBA2J_G0029578
 protein coding gene Chr5:94235887-94643465 (+)
FVB/NJ MGP_FVBNJ_G0029537
 protein coding gene Chr5:93060674-93465737 (+)
LP/J MGP_LPJ_G0029666
 protein coding gene Chr5:98258216-98681989 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029566
 protein coding gene Chr5:110346045-110787517 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030229
 protein coding gene Chr5:96594642-97023117 (+)
PWK/PhJ MGP_PWKPhJ_G0028593
 protein coding gene Chr5:92628612-93031607 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028428
 protein coding gene Chr5:94233681-94664688 (+)
WSB/EiJ MGP_WSBEiJ_G0028953
 protein coding gene Chr5:96907720-97328793 (+)



Homology
more
  • Human Ortholog
    FRAS1, Fraser extracellular matrix complex subunit 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FRAS1, Fraser extracellular matrix complex subunit 1
  • Synonyms
    FRASRS1
  • Links
    NCBI Gene ID: 80144
    neXtProt AC: NX_Q86XX4
    UniProt: Q86XX4

  • Chr Location
    4q21.21
Human Diseases
more
  • Diseases
    2 with Fras1 mouse models; 1 with human FRAS1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 6 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    69 phenotypes from 7 alleles in 10 genetic backgrounds
    5 phenotypes from multigenic genotypes
    9 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for mutations at this locus display a significant amount of embryonic lethality due to hemorrhaging of embryonic blisters. Survival is variable on genetic backgrounds. Kidney development is severely affected and syndactyly is common.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1243
  • Tissues
    196
  • cDNA Data
    44
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034687 Ensembl Gene Model | MGI Sequence Detail 410774 C57BL/6J ±  kb
    transcript ENSMUST00000036019 Ensembl | MGI Sequence Detail 15848 Not Applicable  
    polypeptide ENSMUSP00000043250 Ensembl | MGI Sequence Detail 4010 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 44
      Primer pair 6
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1573, MGI:2442305, MGI:88167
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 28
      Diseases 6
      Gene Ontology 13
      Phenotypes 31
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:335090 McLaughlin MT, et al., Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis. Dev Dyn. 2023 Apr;252(4):483-494
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory