Socs5 MGI Mouse Gene Detail - MGI:2385459 - suppressor of cytokine signaling 5

Symbol

Socs5
Name

suppressor of cytokine signaling 5
Synonyms

1810018L08Rik, Cish5, SOCS-5

Feature Type

protein coding gene
IDs

MGI:2385459
NCBI Gene: 56468
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:87415107-87445267 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 56.93 cM
Mapping Data

3 experiments

SNPs within 2kb

894 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385459	protein coding gene	Chr17:87414707-87445267 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024099	protein coding gene	Chr17:90470905-90500975 (+)
A/J	MGP_AJ_G0024058	protein coding gene	Chr17:87562218-87592094 (+)
AKR/J	MGP_AKRJ_G0024027	protein coding gene	Chr17:89030571-89060493 (+)
BALB/cJ	MGP_BALBcJ_G0024059	protein coding gene	Chr17:87410442-87441632 (+)
C3H/HeJ	MGP_C3HHeJ_G0023824	protein coding gene	Chr17:89902344-89932270 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024504	protein coding gene	Chr17:93595507-93625385 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021943	protein coding gene	Chr17:82705293-82734351 (+)
CAST/EiJ	MGP_CASTEiJ_G0023303	protein coding gene	Chr17:90726316-90757382 (+)
CBA/J	MGP_CBAJ_G0023798	protein coding gene	Chr17:97526992-97556875 (+)
DBA/2J	MGP_DBA2J_G0023926	protein coding gene	Chr17:85999274-86029175 (+)
FVB/NJ	MGP_FVBNJ_G0023892	protein coding gene	Chr17:85509759-85539662 (+)
LP/J	MGP_LPJ_G0024010	protein coding gene	Chr17:91256080-91287225 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023920	protein coding gene	Chr17:97427260-97457182 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024549	protein coding gene	Chr17:89545753-89575676 (+)
PWK/PhJ	MGP_PWKPhJ_G0023048	protein coding gene	Chr17:85638282-85668579 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022859	protein coding gene	Chr17:86302401-86331943 (+)
WSB/EiJ	MGP_WSBEiJ_G0023369	protein coding gene	Chr17:90385577-90416319 (+)

Human Ortholog

SOCS5, suppressor of cytokine signaling 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SOCS5, suppressor of cytokine signaling 5
Synonyms

CIS6, Cish5, CISH6, SOCS-5
Links

HGNC:16852

NCBI Gene ID: 9655

neXtProt AC: NX_O75159

UniProt: O75159
Chr Location

2p21; chr2:46698937-46780245 (+) GRCh38

MGI Vertebrate Homology

Socs5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SOCS5
Gene Tree

Socs5

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Phenotype Summary

2 phenotypes from 1 allele in 2 genetic backgrounds
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

17 strains or lines available

Homozygous null mutants are viable and fertile with normal immune system morphology and function.

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All GO Annotations

25
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

4
cDNA Data

63
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase socs5

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All Sequences

51
RefSeq

10
UniProt

3
CCDS

CCDS29014.1

Ensembl

ENSMUSG00000037104 (Evidence)
NCBI Gene

56468

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037104	Ensembl Gene Model \| MGI Sequence Detail	30161	C57BL/6J	± kb
transcript	ENSMUST00000041369	Ensembl \| MGI Sequence Detail	4648	Not Applicable
polypeptide	ENSMUSP00000038591	Ensembl \| MGI Sequence Detail	536	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015396 suppressor of cytokine signaling 5

(term hierarchy)
PDB

2N34
InterPro Domains

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR022252 SOCS4/SOCS5 domain

IPR037343 SOCS5, SOCS box domain

IPR001496 SOCS box domain

IPR036036 SOCS box-like domain superfamily

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All nucleic 64

cDNA 63

Primer pair 1

Microarray probesets 6

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MGI:1916302

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 10

Phenotypes 5
Earliest

J:51029 Hilton DJ, et al., Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):114-9
Latest

J:257927 Fairchild CL, et al., RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. Development. 2018 Feb 2;145(3):dev155283

TSS for Socs5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr5228	Chr17:87414715-87414750 (+)	-374 bp
Tssr146174	Chr17:87415049-87415112 (+)	-26 bp
Tssr146175	Chr17:87415113-87415130 (+)	15 bp
Tssr146176	Chr17:87424358-87424361 (+)	9,253 bp
Tssr146177	Chr17:87426680-87426691 (+)	11,579 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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