Slu7 MGI Mouse Gene Detail - MGI:2385598 - SLU7 splicing factor homolog (S. cerevisiae)

Symbol

Slu7
Name

SLU7 splicing factor homolog (S. cerevisiae)
Synonyms

D11Ertd730e, D3Bwg0878e, MGC:31026

Feature Type

protein coding gene
IDs

MGI:2385598
NCBI Gene: 193116
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:43324571-43338808 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 25.68 cM
Mapping Data

4 experiments

SNPs within 2kb

648 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385598	protein coding gene	Chr11:43324550-43338809 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018172	protein coding gene	Chr11:42195442-42209634 (+)
A/J	MGP_AJ_G0018144	protein coding gene	Chr11:40590003-40604240 (+)
AKR/J	MGP_AKRJ_G0018108	protein coding gene	Chr11:41776181-41792035 (+)
BALB/cJ	MGP_BALBcJ_G0018113	protein coding gene	Chr11:40773808-40788571 (+)
C3H/HeJ	MGP_C3HHeJ_G0017926	protein coding gene	Chr11:41810197-41825256 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018567	protein coding gene	Chr11:43493933-43508167 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016222	protein coding gene	Chr11:38658235-38673264 (+)
CAST/EiJ	MGP_CASTEiJ_G0017490	protein coding gene	Chr11:41862895-41877920 (+)
CBA/J	MGP_CBAJ_G0017899	protein coding gene	Chr11:45493020-45508732 (+)
DBA/2J	MGP_DBA2J_G0018009	protein coding gene	Chr11:40377133-40391529 (+)
FVB/NJ	MGP_FVBNJ_G0018003	protein coding gene	Chr11:40066013-40080316 (+)
LP/J	MGP_LPJ_G0018081	protein coding gene	Chr11:42445441-42459690 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018027	protein coding gene	Chr11:47143405-47157651 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018606	protein coding gene	Chr11:41931215-41947030 (+)
PWK/PhJ	MGP_PWKPhJ_G0017271	protein coding gene	Chr11:40396829-40411733 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017063	protein coding gene	Chr11:41723954-41742298 (+)
WSB/EiJ	MGP_WSBEiJ_G0017539	protein coding gene	Chr11:41573214-41587564 (+)

Human Ortholog

SLU7, SLU7 homolog, splicing factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLU7, SLU7 homolog, splicing factor
Synonyms

9G8, hSlu7
Links

HGNC:16939

NCBI Gene ID: 10569

neXtProt AC: NX_O95391

UniProt: O95391
Chr Location

5q33.3; chr5:160401641-160421711 (-) GRCh38

MGI Vertebrate Homology

Slu7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLU7
Gene Tree

Slu7

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Phenotype Summary

8 phenotypes from 1 allele in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

4
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Slu7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice heterozygous for a knock-out allele exhibit increased sensitivity to chronic (CCl4-induced) and acute (acetaminophen-induced) liver injury, enhanced oxidative stress, and impaired hepatic functions.

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All GO Annotations

34
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

9
cDNA Data

116
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slu7

ZFIN slu7

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All Sequences

67
RefSeq

8
UniProt

4
CCDS

CCDS24557.1

Ensembl

ENSMUSG00000020409 (Evidence)
NCBI Gene

193116

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020409	Ensembl Gene Model \| MGI Sequence Detail	14238	C57BL/6J	± kb
transcript	ENSMUST00000020681	Ensembl \| MGI Sequence Detail	3625	Not Applicable
polypeptide	ENSMUSP00000020681	Ensembl \| MGI Sequence Detail	585	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015250 pre-mRNA-splicing factor SLU7

(term hierarchy)
InterPro Domains

IPR039974 Pre-mRNA-splicing factor SLU7

IPR021715 Pre-mRNA-splicing factor SLU7 domain

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All nucleic 120

cDNA 117

Primer pair 3

Microarray probesets 11

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MGD-MRK-34222, MGI:106528, MGI:1289335, MGI:2144386

Summaries

All 44

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 13
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slu7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100992	Chr11:43324547-43324610 (+)	8 bp
Tssr100993	Chr11:43332233-43332247 (+)	7,669 bp
Tssr100994	Chr11:43335578-43335597 (+)	11,017 bp
Tssr100995	Chr11:43336005-43336039 (+)	11,451 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24