Mmrn2 MGI Mouse Gene Detail - MGI:2385618

Symbol

Mmrn2
Name

multimerin 2
Synonyms

Emilin3, EndoGlyx-1, ENDOGLYX1

Feature Type

protein coding gene
IDs

MGI:2385618
NCBI Gene: 105450
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr14:34097461-34126244 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 20.81 cM
Mapping Data

1 experiment

SNPs within 2kb

828 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385618	protein coding gene	Chr14:34097422-34126244 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021174	protein coding gene	Chr14:27733739-27757210 (+)
A/J	MGP_AJ_G0021122	protein coding gene	Chr14:26661110-26685274 (+)
AKR/J	MGP_AKRJ_G0021099	protein coding gene	Chr14:27837649-27865443 (+)
BALB/cJ	MGP_BALBcJ_G0021126	protein coding gene	Chr14:26841304-26868064 (+)
C3H/HeJ	MGP_C3HHeJ_G0020909	protein coding gene	Chr14:27758974-27791438 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021558	protein coding gene	Chr14:28788447-28820177 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019120	protein coding gene	Chr14:26682897-26706469 (+)
CAST/EiJ	MGP_CASTEiJ_G0020434	protein coding gene	Chr14:27578941-27603563 (+)
CBA/J	MGP_CBAJ_G0020876	protein coding gene	Chr14:29843098-29876887 (+)
DBA/2J	MGP_DBA2J_G0020998	protein coding gene	Chr14:26695816-26719104 (+)
FVB/NJ	MGP_FVBNJ_G0020982	protein coding gene	Chr14:26652547-26678653 (+)
LP/J	MGP_LPJ_G0021067	protein coding gene	Chr14:28060236-28088401 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021008	protein coding gene	Chr14:28980523-29004709 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021591	protein coding gene	Chr14:27680860-27705512 (+)
PWK/PhJ	MGP_PWKPhJ_G0020182	protein coding gene	Chr14:26180569-26204268 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020006	protein coding gene	Chr14:27282247-27306741 (+)
WSB/EiJ	MGP_WSBEiJ_G0020489	protein coding gene	Chr14:27730353-27755836 (+)

Human Ortholog

MMRN2, multimerin 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MMRN2, multimerin 2
Synonyms

EMILIN-3, EMILIN3, ENDOGLYX-1
Links

HGNC:19888

NCBI Gene ID: 79812

neXtProt AC: NX_Q9H8L6

UniProt: Q9H8L6
Chr Location

10q23.2; chr10:86935540-86969481 (-) GRCh38

MGI Vertebrate Homology

Mmrn2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MMRN2
Gene Tree

Mmrn2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

1
Gene trapped

4
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

54 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display abnormal blood vessel morphology, vascular leakage, and increased density of small vessels in tumors.

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All GO Annotations

31
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

822
Tissues

66
cDNA Data

24
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

44
RefSeq

2
UniProt

2
CCDS

CCDS36876.1

Ensembl

ENSMUSG00000041445 (Evidence)
NCBI Gene

105450

			Length	Strain/Species	Flank
genomic	105450	NCBI Gene Model \| MGI Sequence Detail	28784	C57BL/6J	± kb
transcript	NM_153127	RefSeq \| MGI Sequence Detail	3935	C57BL/6
polypeptide	A6H6E2	UniProt \| EBI \| MGI Sequence Detail	943	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010493 multimerin-2

(term hierarchy)
InterPro Domains

IPR001073 C1q domain

IPR050392 Collagen/C1q domain-containing

IPR011489 EMI domain

IPR008983 Tumour necrosis factor-like domain superfamily
GlyGen

A6H6E2 13 sites, 4 N-linked glycans (6 sites), 1 O-linked glycan (1 site)

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All nucleic 26

cDNA 25

Primer pair 1

Microarray probesets 9

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MGI:2145589

Summaries

All 43

Developmental Gene Expression 5

Gene Ontology 11

Phenotypes 6
Earliest

J:78991 Leimeister C, et al., Developmental expression and biochemical characterization of Emu family members. Dev Biol. 2002 Sep 15;249(2):204-18
Latest

J:298039 Pellicani R, et al., Multimerin-2 maintains vascular stability and permeability. Matrix Biol. 2020 May;87:11-25

TSS for Mmrn2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125076	Chr14:34097445-34097456 (+)	-10 bp
Tssr125077	Chr14:34097474-34097539 (+)	46 bp
Tssr125078	Chr14:34098388-34098427 (+)	947 bp
Tssr125079	Chr14:34100721-34100736 (+)	3,268 bp
Tssr125080	Chr14:34100739-34100752 (+)	3,285 bp
Tssr125081	Chr14:34100795-34100809 (+)	3,341 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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